Diabetes Research and Clinical Practice
Volume 66 , Pages S57-S62 , December 2004

Prevention and treatment of macroangiopathy: focusing on oxidative stress

  • Keun-Gyu Park

      Affiliations

    • Department of Internal Medicine, School of Medicine, Keimyung University Dongsan Medical Center, 194 Dongsan-Dong, Jung-Gu, Daegu 700-712, Republic of Korea
    • ,
  • Mi-Jung Kim

      Affiliations

    • Department of Internal Medicine, School of Medicine, Keimyung University Dongsan Medical Center, 194 Dongsan-Dong, Jung-Gu, Daegu 700-712, Republic of Korea
    • ,
  • Hye-Soon Kim

      Affiliations

    • Department of Internal Medicine, School of Medicine, Keimyung University Dongsan Medical Center, 194 Dongsan-Dong, Jung-Gu, Daegu 700-712, Republic of Korea
    • ,
  • Sang-Jun Lee

      Affiliations

    • Department of Internal Medicine, School of Medicine, Keimyung University Dongsan Medical Center, 194 Dongsan-Dong, Jung-Gu, Daegu 700-712, Republic of Korea
    • ,
  • Dae-Kyu Song

      Affiliations

    • Department of Physiology, Keimyung University School of Medicine, 194 Dongsan-Dong, Jung-Gu, Daegu 700-712, Republic of Korea
    • ,
  • In-Kyu Lee

      Affiliations

    • Department of Internal Medicine, School of Medicine, Keimyung University Dongsan Medical Center, 194 Dongsan-Dong, Jung-Gu, Daegu 700-712, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 53 250 7421; fax: +82 53 250 7892.

Received 18 July 2003 ,Accepted 15 August 2003.

References 

  1. Beckman JA , Creager MA , Libby P . Diabetes and atherosclerosis: epidemiology, pathophysiology, and management . JAMA . 2002;287:2570–2581
  2. Mano T , Masuyama T , Yamamoto K , et al.   Endothelial dysfunction in the early stage of atherosclerosis precedes appearance of intimal lesions assessable with intravascular ultrasound . Am. Heart J. . 1996;131:231–238
  3. Ravikumar R , Deepa R , Shanthirani CS , Mohan V . Comparison of carotid intima-media thickness, arterial stiffness, and brachial artery flow mediated dilatation in diabetic and nondiabetic subjects (The Chennai Urban Population Study [CUPS-9]) . Am. J. Cardiol. . 2002;90:702–707
  4. Meeking DR , Cummings MH , Thorne S , et al.   Endothelial dysfunction in Type 1 diabetic subjects with and without microalbuminuria . Diabet. Med. . 1999;16:841–847
  5. Lee SJ , Lee DW , Kim KS , Lee IK . Effect of estrogen on endothelial dysfunction in postmenopausal women with diabetes . Diabetes Res. Clin. Pract. . 2001;54(Suppl. 2):S81–S92
  6. Williams SB , Cusco JA , Roddy MA , Johnstone MT , Creager MA . Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus . J. Am. Coll. Cardiol. . 1996;27:567–574
  7. Tesfamariam B , Cohen RA . Free radicals mediate endothelial cell dysfunction caused by elevated glucose . Am. J. Physiol. . 1992;263:321–326
  8. Plotnick GD , Corretti MC , Vogel RA . Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal . JAMA . 1997;278:1682–1686
  9. Bae JH , Bassenge E , Kim KB , et al.   Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress . Atherosclerosis . 2001;155:517–523
  10. Packer L , Witt EH , Tritschler HJ . Alpha-Lipoic acid as a biological antioxidant . Free Radic. Biol. Med. . 1995;19:227–250
  11. Packer L , Roy S , Sen CK . Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription . Adv. Pharmacol. . 1997;38:79–101
  12. Evans JL , Goldfine ID , Maddux BA , Grodsky GM . Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes . Endocr. Rev. . 2002;23:599–622
  13. Visioli F , Smith A , Zhang W , Keaney JF , Hagen T , Frei B . Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status . Redox Rep. . 2002;7:223–227
  14. Celermajer DS , Sorensen KE , Gooch VM , et al.   Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis . Lancet . 1992;340:1111–1115
  15. Sorensen KE , Celermajer DS , Georgakopoulos D , Hatcher G , Betteridge DJ , Deanfield JE . Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level . J. Clin. Invest. . 1994;93:50–55
  16. Celermajer DS , Sorensen KE , Georgakopoulos D , et al.   Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults . Circulation . 1993;88:2149–2155
  17. Barenbrock M , Hausberg M , Kosch M , Golubev SA , Kisters K , Rahn KH . Flow-mediated vasodilation and distensibility in relation to intima-media thickness of large arteries in mild essential hypertension . Am. J. Hypertens. . 1999;12:973–979
  18. Lundman P , Eriksson M , Schenck-Gustafsson K , Karpe F , Tornvall P . Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease . Circulation . 1997;96:3266–3268
  19. Hiramatsu K , Arimori S . Increased superoxide production by mononuclear cells of patients with hypertriglyceridemia and diabetes . Diabetes . 1988;37:832–837
  20. Steinberg D . Low density lipoprotein oxidation and its pathobiological significance . J. Biol. Chem. . 1997;272:20963–20966
  21. Kondo A , Muranaka Y , Ohta I , et al.   Relationship between triglyceride concentrations and LDL size evaluated by malondialdehyde-modified LDL . Clin. Chem. . 2001;47:893–900
  22. Baynes JW , Thorpe SR . Role of oxidative stress in diabetic complications: a new perspective on an old paradigm . Diabetes . 1999;48:1–9

PII: S0168-8227(04)00166-4

doi: 10.1016/j.diabres.2003.08.017

Diabetes Research and Clinical Practice
Volume 66 , Pages S57-S62 , December 2004

Article Tools

* Image Usage & Resolution