Diabetes Research and Clinical Practice
Volume 66, Supplement , Pages S49-S51, December 2004

Pericytes and the prevention of diabetic retinopathy

  • Jaetaek Kim

      Affiliations

    • Corresponding Author InformationTel.: +82 2 2260 2398; fax: +82 2 2272 8351.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung-Ang University Hospital, 82-1 Pil-dong, 2Ka Chung-ku, Seoul 100-272, South Korea

Received 22 September 2003; accepted 20 October 2003. published online 19 August 2004.

Abstract 

Diabetic retinopathy is a leading cause of blindness and one of the hallmarks of early diabetic retinopathy is death of pericytes. I studied the effect of glycated albumin (GA) on the retinal pericyte death and assessed the protective effects of some well-known antioxidant materials. GA produced a progressive cytotoxic effect in a near time and dose dependent manner. Among the antioxidant pretreatments, l-ascorbic acid, Trolox, produced a reduction of GA-induced cytototoxicity. N-Acetyl-l-cysteine showed partial effect but taurine had no effect on the GA-toxicity. In conclusion, I demonstrated the effect of GA on the retinal pericyte death and some antioxidants effectively prevented the GA-induced cell death in pericytes.

Keywords:  Pericyte , Glycated albumin , Cytotoxicity , Antioxidants

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PII: S0168-8227(04)00162-7

doi:10.1016/j.diabres.2003.10.027

Diabetes Research and Clinical Practice
Volume 66, Supplement , Pages S49-S51, December 2004

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