« Previous
Next »
Diabetes Research and Clinical Practice
Volume 66
, Pages S27-S32
, December 2004
Prevention of type 1 diabetes: from the view point of β cell damage
References
-
E. Kawasaki, R.G. Gill, G.S. Eisenbarth, Type 1 diabetes, in: G.S. Eisenbarth (Ed.), Endocrine and Organ Specific Autoimmunity, R.G. Landes Co., Austin, TX, 1999, pp. 149–182.
- . Regeneration of pancreatic β cells from intra-islet precursor cells in an experimental model of diabetes . Endocrinology . 2001;142:4956–4968
- Transgenic overexpression of hepatocyte growth factor in the β cell markedly improves islet function and islet transplant outcomes in mice . Diabetes . 2001;50:2752–2762
- . Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and β cell destruction in NOD mice . Diabetes . 1994;43:667–675
-
.
Approaches to type 1 diabetes prevention by intervention in cytokine immunoregulatory circuits
.
Int. J. Exp. Diab. Res
. 2001;2:3–17
- . TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties . Annu. Rev. Immunol . 1989;7:145–173
-
.
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-α and interleukin 1
.
Proc. Natl. Acad. Sci. U.S.A
. 1990;87:968–972
- Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice . Hum. Gene. Ther . 1998;9:1701–1707
- . Alpha-interferon inhibits the development of diabetes in NOD mice . Diabetes . 1998;47:1867–1872
- Interleukin-13 prevents autoimmune diabetes in NOD mice . Diabetes . 1999;48:1522–1528
- Administration of IL-4 prevents autoimmune diabetes but enhances pancreatic insulitis in NOD mice . Clin. Immunol. Immunopathol . 1998;86:209–218
- . TGF-β1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice . J. Immunol . 1998;161:3950–3956
- . Monoclonal anti-tumor necrosis factor antibody renders non-obese diabetic mice hypersensitive to irradiation and enhances insulitis development . Int. Immunol . 1992;4:611–614
- Prevention of diabetes in NOD mice treated with antibody to murine IFN γ . J. Autoimmun . 1991;4:237–248
- Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice . Diabetes . 2000;49:1998–2006
- Targeted expression of the neuropeptide calcitonin gene-related peptide to β cells prevents diabetes in NOD mice . J. Immunol . 1997;158:1409–1416
- Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-β1 . J. Clin. Invest . 1998;102:499–506
- . Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse . J. Immunol . 1999;163:1696–1703
- Suppression of T(h)1 cell activation and prevention of autoimmune diabetes in NOD mice by local expression of viral IL-10 . Int. Immunol . 2001;13:685–694
-
.
Expression of adenoviral E3 transgenes in β cells prevents autoimmune diabetes
.
Proc. Natl. Acad. Sci. U.S.A
. 1997;94:9808–9813
- . Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1β and Fas ligation . Diabetes . 1998;47:727–732
- Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human β cells sorted by flow-cytometry and cultured in vitro . Transplant. Proc . 1995;27:3271–3275
- The role of Fas in autoimmune diabetes . Cell . 1997;89:17–24
- Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice . J. Exp. Med . 1997;186:613–618
- Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus . Diabetologia . 1999;42:1332–1340
- . cFLIP protein prevents tumor necrosis factor-α-mediated induction of caspase-8-dependent apoptosis in insulin-secreting βTc-Tet cells . Diabetes . 2002;51:1805–1814
- Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic β cells from apoptosis . Hum. Gene. Ther . 1996;7:1719–1726
- Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects β cells from cytokine-induced destruction . Diabetes . 1999;48:1223–1229
- . CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse . Biochem. J . 1981;199:393–398
- . Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues . Free Radic. Biol. Med . 1996;20:463–466
- . TNF-α and IFN-γ potentiate the deleterious effects of IL-1β on mouse pancreatic islets mainly via generation of nitric oxide . Cytokine . 1994;6:399–406
- . Does nitric oxide mediate autoimmune destruction of Beta cells? Possible therapuetic interventions in IDDM . Diabetes . 1992;41:897–903
- Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans . Diabetes . 1995;44:753–758
- . Cytokine-induced inhibition of insulin release from mouse pancreatic β cells deficient in inducible nitric oxide synthase . Biochem. Biophys. Res. Commun . 2001;281:396–403
- . Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes . Diabetes . 1999;48:706–713
-
Transgenic copper/zinc superoxide dismutase modulates susceptibility to type I diabetes
.
Proc. Natl. Acad. Sci. U.S.A
. 1994;91:9956–9959
- . Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1β- induced cytotoxicity and reduces nitric oxide production . J. Clin. Invest . 1998;101:1811–1820
- . Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes . Diabetes . 2000;49:1123–1130
- Pancreatic β cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes . J. Exp. Med . 1998;188:1445–1451
- A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T cell clone . Diabetes . 2002;51:347–355
- . The pharmacokinetics of nicotinamide in humans and rodents . Diabetes . 1995;44:152–155
-
.
Meta-analysis of nicotinamide treatment in patients with recent-onset IDDM. The Nicotinamide Trialists
.
Diab. Care
. 1996;19:1357–1363
- DENIS Group, The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes . Diabetes . 1998;47:980–984
-
The European Nicotinamide Diabetes Intervention Trial (ENDIT) Group, E.A. Gale, Intervening before the onset of Type 1 diabetes: baseline data from the European Nicotinamide Diabetes Intervention Trial (ENDIT), Diabetologia 46 (2003) 339–346.
PII: S0168-8227(04)00156-1
doi: 10.1016/j.diabres.2003.09.015
© 2004 Elsevier Ireland Ltd. All rights reserved.
« Previous
Next »
Diabetes Research and Clinical Practice
Volume 66
, Pages S27-S32
, December 2004
