Diabetes Research and Clinical Practice
Volume 66 , Pages S19-S25 , December 2004

Prediction of the risk of type 1 diabetes from polymorphisms in candidate genes

  • Y. Park

      Affiliations

    • Corresponding Author InformationTel.: +82 31 560 2239; fax: +82 31 553 7369.

Received 10 September 2003 ,Accepted 8 October 2003.

References 

  1. Y. Park, G.S. Eisenbarth, Natural History of type 1 diabetes, in: S. Taylor, D. LeRoith, J. Olefsky (Eds.), Diabetes Mellitus: A Fundamantal and Clinical Text, second ed., Lippincott Williams & Wilkins, Philadelphia, PA, 2000, pp. 347–362.
  2. Beyan H , Buckley LR , Yousaf N , Londei M , Leslie RDG . A role for innate immunity in type 1 diabetes? . Diab. Metab. Res. Rev . 2003;19:89–100
  3. Park Y , Ko K , Yang S , et al.   Evaluation of the efficacy of multiple autoantibody screening in Korean patients with IDDM . Acta Diabetol . 2001;37:213–217
  4. S. Choi, Y. Park, H. Park, et al., Development of a new type 1 diabetes-related autoantibody detection method using GAD65/IA-2 fusion protein, in: Perspectives of Diabetes in The New Millennium, Proceedings of the 11th Korea–Japan Symposium on Diabetes Mellitus, Elsevier, Singapore, 2003, pp. 64–66.
  5. Park Y , Park H , Yoo E , Kim D , Yang S . HLA DR3 haplotypes confer susceptibility to T1DM without association with particular immune marker, while HLA DR4 haplotypes confer susceptibility through GAD antibody production . Diabetes . 2002;51:A210
  6. Park Y , Eisenbarth GS . Genetic susceptibility factors of type 1 diabetes in Asians and their functional evaluation . Diab. Metab. Res. Rev . 2001;17:2–11
  7. Park Y , Wang C , Ko K , et al.   Combinations of HLA DR and DQ molecules determine the susceptibility to insulin-dependent diabetes mellitus in Koreans . Hum. Immunol . 1998;59:794–801
  8. Park Y , She J , Wang C , et al.   Common susceptibility and transmission pattern of HLA DRB1-DQB1 haplotypes to Korean and Caucasian patients with type 1 diabetes . J. Clin. Endocrinol. Metab . 2000;85:4538–4542
  9. Park Y , She J , Noble JA , Erlich HA , Eisenbarth GS . Transracial evidence for the influence of the homologous HLA DR-DQ haplotype on transmission of HLA DR4 haplotypes to diabetic children . Tissue Antigens . 2001;57:185–191
  10. Park Y , Lee H , Sanjeevi C , Eisenbarth GS . MIC-A polymorphism is associated with type 1 diabetes in the Korean population . Diab. Care . 2001;24:33–38
  11. Zake LN , Ghaderi M , Park Y , Babu S , Eisenbarth G , Sanjeevi C . MHC class I chain related gene (MIC-A) alleles 5 and 5.1 are transmitted more frequently to type 1 diabetes offsprings in HBDI families . Ann. NY Acad. Sci . 2002;958:309–311
  12. Park Y , Sanjeevi C , Robles D , et al.   HLA genotypes (class II, MIC-A, D6S273): additional association of intra-MHC genes, MICA and D6S273 with Addison’s disease . Tissue Antigens . 2002;60:155–163
  13. Park Y , Jospe E , Babu S , Eisenbarth GS . D6S2223 alleles associated with risk of IDDM in DR3-DQ2/DR4-DQ8 heterozygotes . Diabetes . 1999;48:A183
  14. Patel SD , Cope AP , Congia M , et al.   Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase65 by using HLA-DR (alpha1∗0101, beta1∗0401) transgenic mice . Proc. Natl. Acad. Sci. U.S.A . 1997;94:8082–8087
  15. Wen L , Wong FS , Tang J , et al.   In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes . J. Exp. Med . 2000;191:97–104
  16. Marron M , Zeidler A , Raffel L , et al.   Genetic and physical fine-mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33 . Diabetes . 2000;49:492–499
  17. Ueda H , Howson J , Esposito L , et al.   Association of T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease . Nature . 2003;29:506–511
  18. Park Y , Kim T , Kim D , Sanjeevi C . Natural killer cell immunoglobulin-like receptor (KIR) genes in Korean patients with type 1 diabetes mellitus . Diabetologia . 2003;46:A16
  19. Y. Park, Y. Moon, H. Chung, AIRE-1 (autoimmune regulator type 1) as a regulator of the thymic induction of negative selection, Ann. NY Acad. Sci. 1005 (2003) 431–435.
  20. Anderson M , Venanzi E , Klein L , et al.   Projection of an immunological self shadow within the thymus by the aire protein . Science . 2002;298:1348–1349

PII: S0168-8227(04)00155-X

doi: 10.1016/j.diabres.2003.10.026

Diabetes Research and Clinical Practice
Volume 66 , Pages S19-S25 , December 2004

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