Diabetes Research and Clinical Practice
Volume 65, Issue 2 , Pages 167-173 , August 2004

Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy

  • Sung-Woo Ha

      Affiliations

    • Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Hyun-Ji Kim

      Affiliations

    • Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Jong-Sup Bae

      Affiliations

    • Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Gui-Hwa Jeong

      Affiliations

    • Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Sung-Chang Chung

      Affiliations

    • Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Jung-Guk Kim

      Affiliations

    • Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Sun-Hee Park

      Affiliations

    • Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Yong-Lim Kim

      Affiliations

    • Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Sin Kam

      Affiliations

    • Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • In-San Kim

      Affiliations

    • Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • ,
  • Bo-Wan Kim

      Affiliations

    • Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea
    • Corresponding Author InformationCorresponding author.

Received 30 September 2003 ,Revised 16 January 2004 ,Accepted 22 January 2004.

References 

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  2. Border WA, Ruoslahti E. Transforming growth factor-β in disease, the dark side of tissue repair. J. Clin. Invest. 1992;90:1–7
  3. Border WA, Noble NA. Transforming growth factor-β in tissue fibrosis. N. Engl. J. Med. 1994;331:1286–1292
  4. Sharma K, Ziyadeh FN. Hyperglycemia and diabetic kidney disease; the case for transforming growth factor-β as a key mediator. Diabetes. 1995;44:1139–1146
  5. Korpinen E, Teppo AM, Hukkanen L, Åkerblom HK, Grönhagen-Riska C, Vaarala O. Urinary transforming growth factor-β1 and α1-macroglobulin in children and adolescents with type 1 diabetes. Diabetes Care. 2000;23:664–668
  6. Ellis D, Forrest KY, Erbey J, Orchard TJ. Urinary measurement of transforming growth factor-β and type IV collagen as new marker of renal injury; application in diabetic nephropathy. Clin. Chem. 1998;44:950–956
  7. Sharma K, Ziyadeh FN, Alzahabi B, et al.  Increased renal production of transforming growth factor-β1 in patients with type II diabetes. Diabetes. 1997;46:854–859
  8. Russo LM, Osicka TM, Brammar GC, Candido R, Jerums G, Comper WD. Renal processing of albumin in diabetes and hypertension in rats. Possible role of TGF-β1. Am. J. Nephrol. 2003;23:61–70
  9. Wang SN, LaPage J, Hirschberg R. Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy. Kidney Int. 2000;57:1002–1014
  10. Skonier J, Neubauer M, Madisen L, Bennett K, Plowman GD, Purchio AF. cDNA cloning and sequence analysis of βig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-β. DNA Cell Biol. 1992;11:511–522
  11. Lee SH, Bae JS, Park SH, et al.  Expression of TGF-β-induced matrix protein βig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose. Kidney Int. 2003;64:1012–1021
  12. Gilbert RE, Wilkinson-Berka JL, Johnson DW, et al.  Renal expression of transforming growth factor-β inducible gene-h3 (βig-h3) in normal and diabetic rats. Kidney Int. 1998;54:1052–1062
  13. Caramori ML, Fioretto P, Mauer M. Perspectives in diabetes; the need for early predictors of diabetic nephropathy risk. Is albumin excretion rate sufficient?. Diabetes. 2000;49:1399–1408
  14. Kim JE, Kim SJ, Lee BH, Park RW, Kim KS, Kim IS. Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-β-induced gene, βig-h3. J. Biol. Chem. 2000;275:30907–30915
  15. Sharma K, McGowan TA. TGF-β in diabetic kidney disease; role of novel signaling pathways. Cytokine Growth Factor Rev. 2000;11:115–123
  16. Reeves WB, Andreoli TE. Transforming growth factor-β contributes to progressive diabetic nephropathy. Proc. Natl. Acad. Sci. U.S.A. 2000;97:7667–7669
  17. Sharma K, Ziyadeh FN. Hyperglycemia and diabetic kidney disease: the case for transforming growth factor-β as a key mediator. Diabetes. 1995;44:1139–1146
  18. Fagerudd JA, Groop P-H, Honkanen E, Teppo A-M, Grönhgen-Riska C. Urinary excretion of TGF-β1, PDGF and fibronectin in insulin-dependent diabetes mellitus patients. Kidney Int. 1997;62:S195–S197
  19. Rivarola EWR, Moyses-Neto M, Dantas M, da-Silva CG, Volpini R, Coimbra TM. Transforming growth factor beta activity in urine of patients with type 2 diabetes and diabetic nephropathy. Braz. J. Med. Biol. Res. 1999;32:1526–1528
  20. Ha SW, Bae JS, Yeo HJ, et al.  TGF-β-induced protein, βig-h3 is up-regulated by high glucose in vascular smooth muscle cells. J. Cell Biochem. 2003;88:774–782

PII: S0168-8227(04)00040-3

doi: 10.1016/j.diabres.2004.01.007

Diabetes Research and Clinical Practice
Volume 65, Issue 2 , Pages 167-173 , August 2004

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