Journal Home
Search for

Volume 65, Issue 2, Pages 167-173 (August 2004)


View previous. 12 of 15 View next.

Elevation of urinary βig-h3, transforming growth factor-β-induced protein in patients with type 2 diabetes and nephropathy

Sung-Woo Haa, Hyun-Ji Kimab, Jong-Sup Baeb, Gui-Hwa Jeonga, Sung-Chang Chunga, Jung-Guk Kima, Sun-Hee Parka, Yong-Lim Kima, Sin Kamc, In-San Kimb, Bo-Wan KimaCorresponding Author Informationemail address

Received 30 September 2003; received in revised form 16 January 2004; accepted 22 January 2004.

Abstract 

Transforming growth factor-β (TGF-β) is a pro-sclerotic growth factor implicated in the pathogenesis of diabetic nephropathy. βig-h3 is an extracellular matrix protein which is induced in many cells by TGF-β. This study examined urinary βig-h3 excretion in diabetic patients with elevated urinary albumin excretion and the clinical application of urinary βig-h3 as a marker of diabetic nephropathy. Urinary and serum βig-h3 levels were determined by enzyme-linked immunosorbent assay in 163 type 2 diabetic patients and 101 healthy control subjects of comparable age and weight. The ratio of urinary βig-h3 and TGF-β to creatinine was analyzed in patients with different degree of nephropathy. The βig-h3 to creatinine ratio in urine was elevated in all groups of type 2 diabetics with normoalbuminuria (101.6±9.27), microalbuminuria (120.2±14.48), and overt proteinuria (146.3±16.34), when compared with control subjects (64.8±7.14) (P<0.01). There was a positive correlation between urinary βig-h3 and TGF-β excretion rate and a positive correlation between urinary βig-h3 and albumin excretion rate (AER). These data show that urinary levels of βig-h3 are elevated in type 2 diabetic patients with nephropathy and may be used as a marker of diabetic nephropathy.

a Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea

b Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea

c Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea

Corresponding Author InformationCorresponding author.

PII: S0168-8227(04)00040-3

doi:10.1016/j.diabres.2004.01.007


View previous. 12 of 15 View next.