Diabetes Research and Clinical Practice
Volume 65, Issue 2 , Pages 95-104 , August 2004

Insulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria

  • Yerong Yu

      Affiliations

    • Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, 37 Guo Xue Lane, Chengdu, Sichuan 610041, PR China
    • Corresponding Author InformationCorresponding author. Tel.: +86-28-85422362; fax: +86-28-85501007.
    • ,
  • Lixia Suo

      Affiliations

    • Division of Endocrinology, Daqing Oil Field General Hospital, Daqing, Hilongjiang 163001, PR China
    • ,
  • Hongling Yu

      Affiliations

    • Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, 37 Guo Xue Lane, Chengdu, Sichuan 610041, PR China
    • ,
  • Chun Wang

      Affiliations

    • Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, 37 Guo Xue Lane, Chengdu, Sichuan 610041, PR China
    • ,
  • Hong Tang

      Affiliations

    • Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, 37 Guo Xue Lane, Chengdu, Sichuan 610041, PR China

,Revised 21 January 2004 ,Accepted 23 January 2004.

References 

  1. Deckert T, Yokoyama H, Mathiesen E, Ronn B, Jensen T, Feldt-Rasmussen B, et al.  Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes. BMJ. 1996;312:871–874
  2. Dinneen SF, Gerstein HC. The association of microalbumiburia and mortality in non-insulin-dependent diabetes mellitus. Arch. Int. Med. 1997;157:1413–1418
  3. Borch-Johnsen K, Feldt-Rasmussen B, Strandgaard S, Schroll M, Skov Jensen J. Urinary albumin excretion: an independent predictor of ischemic heart disease. Arterioscler. Thromb. Vasc. Biol. 1999;19:1992–1997
  4. A.D. Baron, M.J. Quon, Insulin action and endothelial function, in: GM. Reaven, A. Laws (Ed.), Insulin Resistance: The Metabolic Syndrome X, Humana Press, Totowa, NJ, 1999, pp. 247–266.
  5. Celermajer DS, Sorensen KE, Gooch VM, Miller OI, Sullivan ID, Lloyd JK, et al.  Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111–1115
  6. Christensen CK, Krusell LR, Mogensen CE. Increased blood pressure in diabetes: essential hypertension or diabetic nephropathy?. Scand. J. Clin. Lab. Invest. 1987;47:363–370
  7. Winocour PH, Harland JOE, Millar JP, Laker MF, Alberti KGMM. Microalbuminuria and associated cardiovascular risk factors in the community. Athersclerosis. 1992;93:71–81
  8. Hsuen WA, Anderson PW. Hypertension, the endothelial cell, and the vascular complications of diabetes mellitus. Hypertension. 1992;20:253–263
  9. McVeigh GE, Brennan GM, Johnston GD, McDermott BJ, McGrath LT, Henry WR, et al.  Impaired endothelium- dependent and independent vasodilation in patients with type 2 (non-insulin- dependent) diabetes mellitus. Diabetologia. 1992;35:771–776
  10. Dogra G, Rich L, Stanton K, Watts GF. Endothelium-dependent and independent vasodilation studied at normoglycaemia in type I diabetes mellitus with and without microalbuminuria. Diabetologia. 2001;44:593–601
  11. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese men. J. Clin. Invest. 1990;85:1844–1852
  12. Laakso M, Edelman SV, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes. 1992;41:1076–1083
  13. Lloyd-Jones DM, Bloch KD. The vascular biology of nitric oxide and its role in atherogenesis. Ann. Rev. Med. 1996;47:365–375
  14. Vischer UM, Emeis JJ, Bilo HJ, Stehouwer CD, Thomsen C, Rasmussen O, et al.  von Wille-brand factor (vWf) as a plasma marker of endothelial activation in diabetes: improved reliability with parallel determination of the vWf propeptide (vWf: AgII). Thromb. Haemost. 1998;80:1002–1007
  15. Lee AJ, Fowkes FG, Lowe GD, Connor JM, Rumley A. Fibrinogen, factor VII and PAI-1 genotypes and the risk of coronary and peripheral atherosclerosis: Edinburgh Artery Study. Thromb. Haemostas. 1999;81:553–560
  16. Bagg W, Ferri C, Desideri G, Gamble G, Ockelford P, Braatvedt GD. The Influences of Obesity and Glycemic Control on Endothelial Activation in Patients with Type 2 Diabetes. J. Clin. Endocrinol. Metab. 2001;86:5491–5497
  17. Pedrinelli R, Dell’omo G, Catapano G, Giampietro O, Carmassi F, Matteucci E, et al.  Microalbuminuria and endothelial dysfunction in essential hypertension. Lancet. 1994;344:14–18
  18. Lip GY, Blann AD, Edmunds E, Beevers DG. Baseline abnormalities of endothelial function and thrombogenesis in relation to prognosis in essential hypertension. Blood Coagulation Fibrinolysis. 2002;13:35–41
  19. Zhu Y, Farrehi PM, Fay WP. Plasminogen activator inhibitor type I enhances neointima formation after oxidative vascular injury in atherosclerosis-prone mice. Circulation. 2001;103:3105–3110
  20. Jansson J-H, Nilsson TK, Johnson O. von Willebrand factor, tissue plasminogen activator, and dehydroepiandrosterone sulphate predict cardiovascular death in a 10-year follow up of survivors of acute myocardial infarction. Heart. 1998;80:334–337
  21. Kornerup K, Nordestgaard BG, Feldt-Rasmussen B, Borch-Johnsen K, Jensen KS, Jensen JS. Transvascular low-density lipoprotein transport in patients with diabetes mellitus (Type 2): a noninvasive in vivo isotope technique. Arterioscler. Thromb. Vasc. Biol. 2002;22:1168–1174
  22. Tan KCB, Ai VHG, Chow WS, Chau MT, Leong L, Lam KSL. Influence of low density lipoprotein (LDL) subfraction profile and LDL oxidation on endothelium-dependent and independent vasodilation in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 1999;84:3212–3216
  23. Axelsen M, Smith U, Eriksson JW, Taskinen MR, Jansson PA. Postprandial hypertriglyceridemia and insulin resistance in normoglycemic first-degree relatives of patients with type 2 diabetes. Ann. Int. Med. 1999;131:27–31
  24. Makimattila S, Liu ML, Vakkilainen J, et al.  Impaired endothelium-dependent vasodilation in type 2 diabetes, relation to LDL size, oxidized LDL, and antioxidants. Diab. Care. 1999;22:973–981
  25. Yudkin JS, Stehouwer CDA, Emeis JJ, Coppack SW. C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?. Arterioscler. Thromb. Vasc. Biol. 1999;19:972–978
  26. Steinberg HO, Baron AD. Vascular function, insulin resistance and fatty acids. Diabetologia. 2002;45:623–634
  27. Steinberg HO, Tarshoby M, Monestel R, Hook G, Cronin J, Johnson A, et al.  Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J. Clin. Invest. 1997;100:1230–1237
  28. Steinberg HO, Paradisi G, Hook G, Crowder K, Cronin J, Baron AD. Fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes. 2000;49:1231–1238
  29. Avogaro A, Calo L, Piarulli F, Miola M, deKreutzenberg S, Maran A, et al.  Effect of acute ketosis on the endothelial function of type I diabetic patients: the role of nitric oxide. Diabetes. 1999;48:391–397
  30. Gupta MP, Steinberg HO, Baron AD, Hart CM. Fatty acids impair nitric oxide production in cultured endothelial cells. J. Invest. Med. 1998;46:288A

☆ The data was presented orally at the Fifth IDF West Pacific Region Congress, Beijing, China on 4–7 May 2002. The title: was “The comparison of insulin resistance magnitude in the type 2 diabetic patients with and without microalbuminuria”.

PII: S0168-8227(04)00039-7

doi: 10.1016/j.diabres.2004.01.006

Diabetes Research and Clinical Practice
Volume 65, Issue 2 , Pages 95-104 , August 2004

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