Diabetes Research and Clinical Practice
Volume 64, Issue 1 , Pages 41-49 , April 2004

ACE gene polymorphism, left ventricular geometry, and mortality in diabetic patients with end-stage renal disease

  • Yumiko Sakka

      Affiliations

    • Division of Nephrology and Hypertension, Diabetes Center, Tokyo Women’s Medical University School of Medicine, 8-1 Kawadacho, Shinjukuku, Tokyo 162-8666, Japan
    • ,
  • Tetsuya Babazono

      Affiliations

    • Division of Nephrology and Hypertension, Diabetes Center, Tokyo Women’s Medical University School of Medicine, 8-1 Kawadacho, Shinjukuku, Tokyo 162-8666, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-3-3353-8111; fax: +81-3-3358-1941.
    • ,
  • Asako Sato

      Affiliations

    • Department of Medicine, Diabetes Center, Institute of Geriatrics, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan
    • ,
  • Noriko Ujihara

      Affiliations

    • Department of Medicine, Institute of Geriatrics, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan
    • ,
  • Yasuhiko Iwamoto

      Affiliations

    • Department of Medicine, Diabetes Center, Institute of Geriatrics, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

Received 16 June 2003 ,Revised 18 September 2003 ,Accepted 7 October 2003.

References 

  1. U.S. Renal Data System: USRDS 2002 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2002.
  2. Nakai S, Shinzato T, Sanaka T, et al.  The current state of chronic dialysis treatment in Japan (as of 31 December 2000). J. Jpn. Soc. Dial. Ther. 2002;35:1155–1184
  3. Ritz E, Strumpf C, Katz F, Wing AJ, Quellhorst E. Hypertension and cardiovascular risk factors in hemodialyzed diabetic patients. Hypertension. 1985;7(6 (Pt. 2)):118–124
  4. Collins AJ, Hanson G, Umen A, Kjellstrand C, Keshaviah P. Changing risk factor demographics in end-stage renal disease patients entering hemodialysis and the impact on long-term mortality. Am. J. Kidney. Dis. 1990;15:422–432
  5. Harnett JD, Parfrey PS, Griffiths SM, Gault MH, Barre P, Guttmann RD. Left ventricular hypertrophy in end-stage renal disease. Nephron. 1988;48:107–115
  6. Ma KW, Greene EL, Raij L. Cardiovascular risk factors in chronic renal failure and hemodialysis populations. Am. J. Kidney Dis. 1992;19:505–513
  7. Stack AG, Saran R. Clinical correlates and mortality impact of left ventricular hypertrophy among new ESRD patients in the United States. Am. J. Kidney Dis. 2002;40:1202–1210
  8. Grossman E, Shemesh J, Shamiss A, Thaler M, Carroll J, Rosenthal T. Left ventricular mass in diabetes–hypertension. Arch. Intern. Med. 1992;152:1001–1004
  9. Gambardella S, Frontoni S, Spallone V, et al.  Increased left ventricular mass in normotensive diabetic patients with autonomic neuropathy. Am. J. Hypertens. 1993;6:97–102
  10. Thuesen L, Christiansen JS, Mogensen CE, Henningsen P. Echocardiographic-determined left ventricular wall characteristics in insulin-dependent diabetic patients. Acta Med. Scand. 1988;224:343–348
  11. Sato A, Tarnow L, Parving H-H. Prevalence of left ventricular hypertrophy in Type I diabetic patients with diabetic nephropathy. Diabetologia. 1999;42:76–80
  12. Adams TD, Yanowitz FG, Fisher AG. Heritability of cardiac size: an echocardiographic and electrocardiographic study of monozygotic and dizygotic twins. Circulation. 1985;71:39–44
  13. Verhaaren HA, Schieken RM, Mosteller M, Hewitt JK, Eaves LJ, Nance WE. Bivariate genetic analysis of left ventricular mass and weight in pubertal twins (the Medical College of Virginia twin study). Am. J. Cardiol. 1991;68:661–668
  14. Schunkert H, Hense H-W, Holmer SR, et al.  Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N. Engl. J. Med. 1994;330:1634–1638
  15. Lindpaintner K, Lee M, Larson MG, et al.  Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N. Engl. J. Med. 1996;334:1023–1028
  16. Lechin M, Quinones MA, Omran A, et al.  Angiotensin-I converting enzyme genotypes and left ventricular hypertrophy in patients with hypertrophic cardiomyopathy. Circulation. 1995;92:1808–1812
  17. Osono E, Kurihara S, Hayama N, et al.  Insertion/deletion polymorphism in intron 16 of the ACE gene and left ventricular hypertrophy in patients with end-stage renal disease. Am. J. Kidney Dis. 1998;32:725–730
  18. Nagahara T, Ishigami T, Sano T. Angiotensin-converting enzyme gene insertion/deletion polymorphism and left ventricular hypertrophy in hemodialysis patients. Jpn. Heart J. 1997;38:821–830
  19. Yildiz A, Akkaya V, Hatemi AC, et al.  No association between deletion-type angiotensin-converting enzyme gene polymorphism and left-ventricular hypertrophy in hemodialysis patients. Nephron. 2000;84:130–135
  20. Marre M, Bernadet P, Gallois Y, et al.  Relationships between angiotensin I converting enzyme gene polymorphism. Diabetes. 1994;43:384–388
  21. Schmidt S, Schone N, Ritz E. Association of ACE gene polymorphism and diabetic nephropathy? The Diabetic Nephropathy Study Group. Kidney Int. 1995;47:1176–1181
  22. Tarnow L, Cambien F, Rossing P, et al.  Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. Diabetes. 1995;44:489–494
  23. Tomino Y, Makita Y, Shike T, et al.  Relationship between polymorphism in the angiotensinogen, angiotensin-converting enzyme or angiotensin II receptor and renal progression in Japanese NIDDM patients. Nephron. 1999;82:139–144
  24. Miura J, Uchigata Y, Yokoyama H, Omori Y, Iwamoto Y. Genetic polymorphism of renin-angiotensin system is not associated with diabetic vascular complications in Japanese subjects with long-term insulin dependent diabetes mellitus. Diabetes Res. Clin. Pract. 1999;45:41–49
  25. Palmer BR, Pilbrow AP, Yandle TG, et al.  Angiotensin-converting enzyme gene polymorphism interacts with left ventricular ejection fraction and brain natriuretic peptide levels to predict mortality after myocardial infarction. J. Am. Colloid Cardiol. 2003;41:729–736
  26. Losito A, Parente B, Cao PG, Jeffery S, Afzal AR. ACE gene polymorphism and survival in atherosclerotic renovascular disease. Am. J. Kidney Dis. 2000;35:211–215
  27. Higashiuesato Y, Tana T, Tozawa M, et al.  Angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and survival in a cohort of chronic hemodialysis patients. Clin. Nephrol. 2002;58:370–375
  28. Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man: anatomic validation of the method. Circulation. 1977;55:613–618
  29. Savage DD, Garrison RJ, Kannel WB, et al.  The spectrum of left ventricular hypertrophy in a general population sample: the Framingham study. Circulation. 1987;75(1):26–33
  30. R.B. Devereux, M.J. Roman, Evaluation of cardiac and vascular structure by echocardiography and other noninvasive techniques, in: J.H. Laragh, B.M. Brenner (Eds.), Hypertension: Pathophysiology, Diagnosis, Treatment, second ed. Raven Press, New York, 1995, pp. 1969–1985.
  31. Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH. Relation of left ventricular mass and geometry to morbidity in uncomplicated essential hypertension. Ann. Intern. Med. 1991;114:345–352
  32. Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the human angiotensin converting enzyme gene (DCP1) (dipeptidylcarboxypeptidase 1). Nucleic Acids Res. 1992;20:1433
  33. Babazono T, Tomonaga O, Yano K, et al.  Continuous ambulatory peritoneal dialysis (CAPD) in diabetic patients: five-year’s experience at a single institute (Abstract). Perit. Dial. Int. 1993;11:A23
  34. B.H. Margolin, Test for trend in proportions, in: S. Klotz, N.L. Johnson (Eds.), Encyclopedia of Statistical Sciences, vol. 9, New York, Wiley, 1988, pp. 334–336.
  35. Higaki J, Baba S, Katsuya T, et al.  Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: The Suita Study. Circulation. 2000;101:2060–2065
  36. Matsubara M, Suzuki M, Fujiwara T, et al.  Angiotensin-converting enzyme I/D polymorphism and hypertension: The Ohasama study. J. Hypertens. 2002;20:1121–1126
  37. Gohda T, Makita Y, Shike T, et al.  Association of the DD genotype and development of Japanese type 2 diabetic nephropathy. Clin. Nephrol. 2001;56:475–480
  38. Cambien F, Poirier O, Lecerf L, et al.  Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature. 1992;359:641–644
  39. Prasad N, O’Kane KP, Johnstone HA, et al.  The relationship between blood pressure and left ventricular mass in essential hypertension is observed only in the presence of the angiotensin-converting enzyme gene deletion allele. QJM. 1994;87:659–662
  40. Gharavi AG, Lipkowitz MS, Diamond JA, Jhang JS, Phillips RA. Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension. Am. J. Cardiol. 1996;77:1315–1319
  41. Anonymous: Freely Associating, Nat. Genet. 22 (1999) 1–2.
  42. Grimm R, Rettig R. Association studies between the angiotensin-converting enzyme insertion/deletion polymorphism and hypertension: still interesting. J. Hypertens. 2002;20:1049–1051
  43. London GM. Cardiovascular disease in chronic renal failure: pathophysiologic aspects. Semin. Dial. 2003;16:85–94
  44. Foley RN. Clinical epidemiology of cardiac disease in dialysis patients: left ventricular hypertrophy, ischemic heart disease, and cardiac failure. Semin. Dial. 2003;16:111–117
  45. Harden PN, Geddes C, Rowe PA, et al.  Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy. Lancet. 1995;345:1540–1542
  46. Lowrie EG, Lew NL. Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am. J. Kidney Dis. 1990;15:458–482
  47. Owen WF, Lew NL, Liu Y, Lowrie EG, Lazarus JM. The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N. Engl. J. Med. 1993;329:1001–1006

PII: S0168-8227(03)00258-4

doi: 10.1016/j.diabres.2003.10.010

Diabetes Research and Clinical Practice
Volume 64, Issue 1 , Pages 41-49 , April 2004

Article Tools

* Image Usage & Resolution