Diabetes Research and Clinical Practice
Volume 62, Issue 3 , Pages 197-201 , December 2003

−308 Nco I polymorphism of tumour necrosis factor α in overweight Caucasians

  • Alison M. Morris

      Affiliations

    • Department of Physiology, Adelaide University, Adelaide, SA 5000, Australia
    • Corresponding Author InformationCorresponding author. Present address: Department of Endocrinology, UCHSC, Campus Box B-151, 4200 E. Ninth Ave, Denver, CO 80262, USA
    • ,
  • Leonie K. Heilbronn

      Affiliations

    • Department of Physiology, Adelaide University, Adelaide, SA 5000, Australia
    • ,
  • Manny Noakes

      Affiliations

    • CSIRO Health Sciences and Nutrition, Adelaide, SA 5000, Australia
    • ,
  • Karen L. Kind

      Affiliations

    • CSIRO Health Sciences and Nutrition, Adelaide, SA 5000, Australia
    • ,
  • Peter M. Clifton

      Affiliations

    • CSIRO Health Sciences and Nutrition, Adelaide, SA 5000, Australia

Received 18 March 2003 ,Revised 17 July 2003 ,Accepted 4 August 2003.

References 

  1. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 1995;95(5):2409–2415
  2. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc. Natl. Acad. Sci. USA. 1997;94(7):3195–3199
  3. Hamann A, Mantzoros C, Vidal-Puig A, Flier JS. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM). Biochem. Biophys. Res. Commun. 1995;211(3):833–839
  4. Fernandez-Real JM, Gutierrez C, Ricart W, et al.  The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels. Diabetes. 1997;46(9):1468–1472
  5. Herrmann SM, Ricard S, Nicaud V, et al.  Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity. Eur. J. Clin. Invest. 1998;28(1):59–66
  6. Hoffstedt J, Eriksson P, Hellstrom L, et al.  Excessive fat accumulation is associated with the TNF alpha−308 G/A promoter polymorphism in women but not in men. Diabetologia. 2000;43(1):117–120
  7. Day CP, Grove J, Daly AK, et al.  Tumour necrosis factor-alpha gene promoter polymorphism and decreased insulin resistance. Diabetologia. 1998;41(4):430–434
  8. Brand E, Schorr U, Kunz I, Kertmen E, Ringel J, Distler A, et al. Tumor necrosis factor-alpha−308 G/A polymorphism in obese Caucasians. Int. J. Obes. Relat. Metab. Disord. 2001;25(4):581–585
  9. Dalziel B, Gosby AK, Richman RM, Bryson JM, Caterson ID. Association of the TNF-alpha −308 G/A promoter polymorphism with insulin resistance in obesity. Obes. Res. 2002;10(5):401–407
  10. Walston J, Seibert M, Yen CJ, Cheskin LJ, Andersen R. Tumor necrosis factor-alpha−238 and −308 polymorphisms do not associated with traits related to obesity and insulin resistance. Diabetes. 1999;48(10):2096–2098
  11. Rasmussen SK, Urhammer SA, Jensen JN, Hansen T, Borch-Johnsen K, Pedersen O. The −238 and −308 G-A polymorphisms of the tumor necrosis factor alpha gene promoter are not associated with features of the insulin resistance syndrome or altered birth weight in Danish Caucasians. J. Clin. Endocrinol. Metab. 2000;85(4):1731–1734
  12. da Sliva B, Gapstur SM, Achenbach YH, Schuh TS, Kotlar TJ, Liu K, et al. Lack of association between the −308 polymorphism of the tumor necrosis factor-alpha gene and the insulin resistance syndrome. J. Invest. Med. 2000;48(4):236–244
  13. Koch M, Rett K, Volk A, et al.  The tumour necrosis factor alpha −238G→A and −308G→A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients. Diabetologia. 2000;43(2):181–184
  14. Ishii T, Hirose H, Saito I, Nishikai K, Maruyama H, Saruta T. Tumor necrosis factor alpha gene G−308A polymorphism, insulin resistance, and fasting plasma glucose in young, older, and diabetic Japanese men. Metabolism. 2000;49(12):1616–1618
  15. Furuta M, Yano Y, Ito K, et al.  Relationship of the tumor necrosis factor-alpha −308 A/G promoter polymorphism with insulin sensitivity and abdominal fat distribution in Japanese patients with type 2 diabetes mellitus. Diabetes Res. Clin. Pract. 2002;56(2):141–145
  16. Foster CB, Lehrnbecher T, Mol F, et al.  Host defense molecule polymorphisms influence the risk for immune- mediated complications in chronic granulomatous disease. J. Clin. Invest. 1998;102(12):2146–2155
  17. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha and obesity-induced insulin resistance. Science. 1996;271(5249):665–668

PII: S0168-8227(03)00180-3

doi: 10.1016/j.diabres.2003.08.002

Diabetes Research and Clinical Practice
Volume 62, Issue 3 , Pages 197-201 , December 2003

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