Diabetes Research and Clinical Practice
Volume 62, Issue 3 , Pages 203-209 , December 2003

Stroke is related to lower serum thyrotropin levels in patients with diabetes mellitus

  • Giuseppe Seghieri

      Affiliations

    • Department of Internal Medicine, Spedali Riuniti, Via Monte Sabotino 96/A, 51100 Pistoia, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-338-694-1642; fax: +39-573-372-005
  • ,
  • Gianluca Bardini

      Affiliations

    • Department of Internal Medicine, Spedali Riuniti, Via Monte Sabotino 96/A, 51100 Pistoia, Italy
  • ,
  • Stefano Fascetti

      Affiliations

    • Department of Internal Medicine, Ospedale della Versilia, Viareggio, Italy
  • ,
  • Daniela Moruzzo

      Affiliations

    • Department of Internal Medicine, Ospedale della Versilia, Viareggio, Italy
  • ,
  • Flavia Franconi

      Affiliations

    • Department of Pharmacology and Center for Biotechnology Development and Biodiversity Research, University of Sassari, Sassari, Italy

Received 24 June 2003 ,Revised 31 July 2003 ,Accepted 4 August 2003.

References 

  1. Klein I, Ojamaa K. Mechanism of disease: thyroid hormone and the cardiovascular system. New Engl. J. Med. 2001;344:501–509
  2. Polikar R, Burger AG, Scherrer U, Nicod P. The thyroid and the heart. Circulation. 1993;87:1435–1441
  3. Woeber KA. Thyrotoxicosis and the heart. New Engl. J. Med. 1992;327:94–98
  4. Parle JV, Maisonneuve P, Sheppard MC, Boyle P, Franklyn JA. Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet. 2001;358:861–865
  5. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JCM. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann. Intern. Med. 2000;132:270–278
  6. Kabadi UM. Thyrotropin dysregulation during a non-thyroidal illness: transient hypothalamic hypothyroidism?. J. Endocrinol. Invest. 2001;24:178–182
  7. Hagg E, Asplund K, Eriksson S, Lithner F, Strand T, Wester PO. Serum thyroid-stimulating hormone in cerebrovascular disease. Acta Med. Scand. 1986;219:53–58
  8. Pepper GM, Koenigsberg R, Zito JL, Deutsch S. Alteration of serum pituitary hormone levels in postmenopausal women with stroke. Stroke. 1993;24:805–808
  9. Small M, Cohen HN, MacLean JA, Beastall GH, MacCuish AC. Impaired thyrotrophin secretion following the administration of thyrotrophin-releasing hormone in type II diabetes mellitus. Postgrad. Med. J. 1986;62:445–448
  10. Proces S, Delgrange E, Vander Borght TV, Jamart J, Donckier JE. Minor alterations in thyroid-function tests associated with diabetes mellitus and obesity in outpatients without known thyroid illness. Acta Clin. Belg. 2001;56:86–90
  11. Celani MF, Bonati ME, Stucci M. Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus. Diabetes Res. 1994;27:15–25
  12. Perros P, McCrimmon RJ, Shaw G, Frier BM. Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet. Med. 1995;12:622–627
  13. World Health Organization. Proposal for the multinational monitoring of trends and determinants in cardiovascular disease (MONICA Project). WHO/MNC/82.1 Rev. 1., 1983.
  14. Bagchi N, Brown TR, Shivers B, Lucas S, Mack RE. Decreased thyroidal response to thyrotropin in diabetic mice. Endocrinology. 1981;109:1428–1432
  15. Chamras H, Hershman JM. Effect of diabetes mellitus on thyrotropin release from isolated rat thyrotrophs. Am. J. Med. Sci. 1990;300:16–21
  16. Bagchi N, Palaniswami N, Desai H, Felicetta J, Brown TR. Decreased thyroidal response to thyrotropin in type II diabetes mellitus. Metabolism. 1988;37:669–671
  17. Kabadi UM, Premachandra BN. Low triiodothyronine and raised reverse triiodothyronine levels in patients over fifty years of age who have type II diabetes mellitus: influence of metabolic control, not age. J. Am. Geriatr. Soc. 1984;32:375–379
  18. Schlienger JL, Anceau A, Chabrier G, North ML, Stephan F. Effect of diabetic control on the level of circulating thyroid hormones. Diabetologia. 1982;22:486–488
  19. Kabadi UM. Serum T3 and reverse T3 concentrations: indices of metabolic control in diabetes mellitus. Diabetes Res. 1986;3:417–421
  20. Kabadi UM. Impaired pituitary thyrotroph function in uncontrolled type II diabetes mellitus: normalization on recovery. J. Clin. Endocrinol. Metab. 1984;59:521–525
  21. Iervasi G, Pingitore A, Landi P, Raciti M, Ripoli A, Scarlattini M, et al.  Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease. Circulation. 2003;107:708–713

PII: S0168-8227(03)00179-7

doi: 10.1016/j.diabres.2003.08.001

Diabetes Research and Clinical Practice
Volume 62, Issue 3 , Pages 203-209 , December 2003