Diabetes Research and Clinical Practice
Volume 62, Issue 3 , Pages 139-148 , December 2003

Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats

  • Bolin Qin

      Affiliations

    • Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    • ,
  • Masaru Nagasaki

      Affiliations

    • Research Center of Health, Physical Fitness and Sports, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    • ,
  • Ming Ren

      Affiliations

    • Department of Visual Neuroscience, Graduate School of Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    • ,
  • Gustavo Bajotto

      Affiliations

    • Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    • ,
  • Yoshiharu Oshida

      Affiliations

    • Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    • Research Center of Health, Physical Fitness and Sports, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    • ,
  • Yuzo Sato

      Affiliations

    • Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    • Research Center of Health, Physical Fitness and Sports, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-52-789-3962; fax: +81-52-789-3962/3957

Received 12 March 2003 ,Revised 18 June 2003 ,Accepted 17 July 2003.

References 

  1. F.S. Leung, A.Y., in: Encyclopedia of common natural ingredients used in foods, drugs, and cosmetics, second ed., Wiley, New York, 1996, pp. 168–170.
  2. Toriizuka K. Basic lecture of Kampo medicine: pharmacological effect of cinnamon. Kampo Med. 1998;11:431–436
  3. Broadhurst CL, Polansky MM, Anderson RA. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J. Agric. Food Chem. 2000;48:849–852
  4. Khan A, Bryden NA, Polansky MM, Anderson RA. Insulin potentiating factor and chromium content of selected foods and spices. Biol. Trace Elem. Res. 1990;24:183–188
  5. Imparl-Radosevich J, Deas S, Polansky MM, Baedke DA, Ingebritsen TS, Anderson RA, et al. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: implications for cinnamon regulation of insulin signalling. Horm. Res. 1998;50:177–182
  6. Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J. Am. Coll. Nutr. 2001;20:327–336
  7. Czech MP. Molecular actions of insulin on glucose transport. Annu. Rev. Nutr. 1995;15:441–471
  8. Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol. Rev. 1995;75:473–486
  9. Kahn CR. Banting lecture. Insulin action, diabetogenes, and the cause of type 2 diabetes. Diabetes. 1994;43:1066–1084
  10. Olefsky JM, Kolterman OG, Scarlett JA. Insulin action and resistance in obesity and noninsulin-dependent type 2 diabetes mellitus. Am. J. Physiol. 1982;243:E15–E30
  11. Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ, Dohm GL. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J. Clin. Invest. 1995;95:2195–2204
  12. Bjornholm M, Kawano Y, Lehtihet M, Zierath JR. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes. 1997;46:524–527
  13. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes. 1981;30:1000–1007
  14. DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type 2) diabetes mellitus. J. Clin. Invest. 1985;76:149–155
  15. Li L, Oshida Y, Kusunoki M, Yamanouchi K, Johansson BL, Wahren J, et al. Rat C peptide I and II stimulate glucose utilization in STZ-induced diabetic rats. Diabetologia. 1999;42:958–964
  16. Oshida Y, Tachi Y, Morishita Y, Kitakoshi K, Fuku N, Han YQ, et al. Nitric oxide decreases insulin resistance induced by high-fructose feeding. Horm. Metab. Res. 2000;32:339–342
  17. Hu X, Sato J, Oshida Y, Xu M, Bajotto G, Sato Y. Effect of Gosha-jinki-gan (chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on insulin resistance in streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pract. 2003;59:103–111
  18. Nagasaki M, Nakai N, Oshida Y, Li Z, Xu M, Obayashi M, et al. Exercise training prevents maturation-induced decreases in insulin receptor substrate-1 and phosphatidylinositol 3-kinase in rat skeletal muscle. Metabolism. 2000;49:954–959
  19. Bjorntorp P, Sjostrom L. Carbohydrate storage in man: speculations and some quantitative considerations. Metabolism. 1978;27:1853–1865
  20. Marin P, Rebuffe-Scrive M, Smith U, Bjorntorp P. Glucose uptake in human adipose tissue. Metabolism. 1987;36:1154–1160
  21. DeFronzo RA. Lilly lecture, The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. 1987;37(1988):667–687
  22. Tominaga M, Kimura M, Sugiyama K, Abe T, Igarashi K, Igarashi M, et al  Effects of seishin-renshi-in and Gymnema sylvestre on insulin resistance in streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pract. 1995;29:11–17
  23. Smith D, Rossetti L, Ferrannini E, Johnson CM, Cobelli C, Toffolo G, et al. In vivo glucose metabolism in the awake rat: tracer and insulin clamp studies. Metabolism. 1987;36:1167–1174
  24. Lam TK, Yoshii H, Haber CA, Bogdanovic E, Lam L, Fantus IG, et al. Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta. Am. J. Physiol. Endocrinol. Metab. 2002;283:E682–E691
  25. Khan CR. Insulin resistance, insulin insensitivity and insulin unresponsiveness: a necessary distinction. Metabolism. 1978;27:1893–1902
  26. Olefsky JM, Kolterman OG, Scarlett JA. Insulin action and resistance in obesity and noninsulin-dependent type 2 diabetes mellitus. Am. J. Physiol. 1999;243:E15–E30
  27. Kahn CR, White MF. The insulin receptor and the molecular mechanism of insulin action. J. Clin. Invest. 1988;82:1151–1156
  28. White MF. The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem. 1998;182:3–11
  29. Hara K, Yonezawa K, Sakaue H, Ando A, Kotani K, Kitamura T, et al  1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc. Natl. Acad. Sci. USA. 1994;91:7415–7419
  30. Anai M, Funaki M, Ogihara T, Terasaki J, Inukai K, Katagiri H, et al. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes. 1998;47:13–23
  31. Araki E, Lipes MA, Patti ME, Bruning JC, Haag BR, Johnson RS, et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 1994;372:186–190
  32. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, et al  Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature. 1994;372:182–186
  33. Yamauchi T, Tobe K, Tamemoto H, Ueki K, Kaburagi Y, Yamamoto-Honda R, et al. Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol. Cell. Biol. 1996;16:3074–3084
  34. Handberg A, Vaag A, Vinten J, Beck-Nielsen H. Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1993;36:668–674
  35. Pratipanawatr W, Pratipanawatr T, Cusi K, Berria R, Adams JM, Jenkinson CP, et al. Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation. Diabetes. 2001;50:2572–2578
  36. Storgaard H, Song XM, Jensen CB, Madsbad S, Bjornholm M, Vaag A, et al. Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected]. Diabetes. 2001;50:2770–2778
  37. Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, et al. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J. Clin. Invest. 2000;105:311–320
  38. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol. 1994;14:4902–4911
  39. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J. Biol. Chem. 1994;269:3568–3573
  40. Folli F, Saad MJ, Backer JM, Kahn CR. Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus. J. Clin. Invest. 1993;92:1787–1794

PII: S0168-8227(03)00173-6

doi: 10.1016/S0168-8227(03)00173-6

Diabetes Research and Clinical Practice
Volume 62, Issue 3 , Pages 139-148 , December 2003

Article Tools

* Image Usage & Resolution