Diabetes Research and Clinical Practice
Volume 62, Issue 1 , Pages 55-59 , October 2003

The association of Pro12Ala polymorphism in PPARγ2 with lower carotid artery IMT in Japanese

  • E. Iwata

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • I. Yamamoto

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • T. Motomura

      Affiliations

    • Second Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan
    • ,
  • S. Tsubakimori

      Affiliations

    • Laboratory of Clinical Medicine, NTT West Osaka Hospital, Osaka, Japan
    • ,
  • S. Nohnen

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • M. Ohmoto

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • T. Igarashi

      Affiliations

    • Second Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan
    • ,
  • J. Azuma

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-6-6879-8258; fax: +81-6-6879-8259

Received 27 January 2003 ,Revised 4 June 2003 ,Accepted 19 June 2003.

References 

  1. Kubota N, Terauchi Y, Miki H, et al.  PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell. 1999;4:597–609
  2. Deeb SS, Fajas L, Nemoto M, et al.  Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat. Genet. 1998;20:284–287
  3. Hara K, Okada T, Tobe K, et al.  The Pro12Ala polymorphism in PPARγ2 may confer resistance to type 2 diabetes. Biochem. Biophys. Res. Commun. 2000;271:212–216
  4. Altshuler D, Hirschhorn JN, Klannemark M, et al.  The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 2000;26:76–79
  5. Yamasaki Y, Kawamori R, Matsushima H, et al.  Atherosclerosis in carotid artery of young IDDM patients monitored by ultrasound high-resolution B-mode imaging. Diabetes. 1994;43:634–639
  6. Ek J, Urhammer SA, Sorensen TIA, Andersen T, Auwerx J, Pedersen O. Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-γ2 (PPAR-γ2): divergent modulating effects on body mass index in obese and lean Caucasian men. Diabetologia. 1999;42:892–895
  7. Mori H, Ikegami H, Kawaguchi Y, et al.  The Pro12Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population. Possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes. 2001;50:891–894
  8. Iwata E, Matsuda H, Fukuda T, et al.  Mutations of the peroxisome proliferator-activated receptor γ (PPAR γ) gene in a Japanese population: the Pro12Ala mutation in PPAR γ2 is associated with lower concentration of serum total and non-HDL cholesterol. Diabetologia. 2001;44:1354–1356
  9. Ylitalo K, Syvanne M, Salonen R, Nuotio I, Taskinen MR, Salonen JT. Carotid artery intima-media thickness in Finnish families with familial combined hyperlipidemia. Atherosclerosis. 2002;162:171–178
  10. Meirhaeghe , Fajas L, Helbecque N, et al.  Impact of the peroxisome proliferator activated receptor gamma2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus. Int. J. Obes. 2000;24:195–199

PII: S0168-8227(03)00161-X

doi: 10.1016/S0168-8227(03)00161-X

Diabetes Research and Clinical Practice
Volume 62, Issue 1 , Pages 55-59 , October 2003

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