Diabetes Research and Clinical Practice
Volume 61 , Pages S35-S39 , July 2003

Looking to the future: diabetic neuropathy and effects of rosuvastatin on neurovascular function in diabetes models

References 

  1. Cameron NE, Cotter MA. Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes. 1997;46(Suppl. 2):S31–S37
  2. Cameron NE, Eaton SE, Cotter MA, Tesfaye S. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia. 2001;44:1973–1988
  3. Stalker TJ, Lefer AM, Scalia R. A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br. J. Pharmacol. 2001;133:406–412
  4. Li W, Asagami T, McTaggart F, Tsao PS. The novel HMG-CoA reductase inhibitor, rosuvastatin, attenuates monocyte adhesion in a murine model of hypercholesterolemia. Circulation. 2001;104(Suppl. II):II-212
  5. Hermann M, Ruschitzka F, Camici G, Lüscher TF. Rosuvastatin improves endothelial dysfunction in a rat model of normocholesterolemic mineralocorticoid hypertension. Eur. Heart J. 2002;23(Suppl.):363; abstract 1939
  6. Jones SP, Gibson MF, Rimmer DM, Gibson TM, Sharp BR, Lefer DJ. Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor. J. Am. Coll. Cardiol. 2002;40:1172–1178
  7. Laufs U, Nickenig G, Böhm M, Gertz K. Rosuvastatin, a new HMG-CoA reductase inhibitor, up-regulates endothelial nitric oxide synthase and protects from stroke in mice. Eur. Heart J. 2002;23(Suppl.):499
  8. Werner N, Priller J, Laufs U, et al.  Endothelial progenitor cells modulate vascular re-endothelialization and neointima formation. Effect of HMG CoA reductase inhibition. Eur. Heart J. 2002;23(Suppl.):500
  9. Yagihashi S. Pathology and pathogenetic mechanisms of diabetic neuropathy. Diab. Metab. Rev. 1995;11:193–225
  10. Sima AAF, Sugimoto K. Experimental diabetic neuropathy: an update. Diabetologia. 1999;42:773–788
  11. Cameron NE, Cotter MA. The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications. Diab. Metab. Res. 1994;10:189–224
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  13. Cameron NE, Cotter MA. Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes. Diab. Res. Clin. Pract. 1999;45:137–146
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  15. Tesfaye S, Stevens L, Stephenson J, et al.  The prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM complications study. Diabetologia. 1996;39:1377–1384
  16. Watts GF, O'Brien SF, Silvester W, Millar JA. Impaired endothelium-dependent and -independent dilatation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes: role of dyslipidemia. Clin. Sci. (Colch.). 1996;91:567–573
  17. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 1999;48:1–9
  18. Cameron NE, Inkster ME, Nangle MR, Smith GJ, McTaggart F, Cotter MA. Effects of rosuvastatin, a new HMG-CoA reductase inhibitor, on neurovascular function in diabetic rats. Diabetes. 2001;50(Suppl. 2):A184

PII: S0168-8227(03)00123-2

doi: 10.1016/S0168-8227(03)00123-2

Diabetes Research and Clinical Practice
Volume 61 , Pages S35-S39 , July 2003