Diabetes Research and Clinical Practice
Volume 61, Issue 2 , Pages 133-136, August 2003

Diabetic retinopathy in Euro-Brazilian type 2 diabetic patients: relationship with polymorphisms in the aldose reductase, the plasminogen activator inhibitor-1 and the methylenetetrahydrofolate reductase genes

  • Katia G. Santos

      Affiliations

    • Department of Genetics, Instituto de Biociencias, Federal University of Rio Grande do Sul (UFRGS), Caixa Postal 15053, 91501-970 Porto Alegre, RS, Brazil
    • ,
  • Balduino Tschiedel

      Affiliations

    • Endocrinology Service, Grupo Hospitalar Conceição, Porto Alegre, RS, Brazil
    • ,
  • João Schneider

      Affiliations

    • Ophthalmology Service, Grupo Hospitalar Conceição, Porto Alegre, RS, Brazil
    • ,
  • Katia Souto

      Affiliations

    • Endocrinology Service, Grupo Hospitalar Conceição, Porto Alegre, RS, Brazil
    • ,
  • Israel Roisenberg

      Affiliations

    • Department of Genetics, Instituto de Biociencias, Federal University of Rio Grande do Sul (UFRGS), Caixa Postal 15053, 91501-970 Porto Alegre, RS, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-51-3316-6736; fax: +55-51-3316-7311

Received 11 April 2002; received in revised form 13 March 2003; accepted 16 April 2003.

Abstract 

We investigated the relationship between diabetic retinopathy (DR) and three polymorphisms, C(-106)T in the aldose reductase (ALR2) gene, 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene and C677T in the methylenetetrahydrofolate reductase (MTHFR) gene, in 210 Euro-Brazilian type 2 diabetic patients. Retinopathy was evaluated by funduscopic examination and genotype analysis was performed using the polymerase chain reaction and allele-specific restriction. Retinopathy was detected in 47% of the patients. There were no significant differences in allele or genotype distributions between patients with or without retinopathy for all polymorphisms. Thus, the three polymorphisms are not related to the presence of DR in Euro-Brazilian type 2 diabetic patients.

Keywords: Diabetic retinopathy, Type 2 diabetes mellitus, Polymorphisms

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PII: S0168-8227(03)00112-8

doi:10.1016/S0168-8227(03)00112-8

Diabetes Research and Clinical Practice
Volume 61, Issue 2 , Pages 133-136, August 2003

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