Diabetes Research and Clinical Practice
Volume 61, Issue 2 , Pages 89-92 , August 2003

Insulin lispro reduces insulin antibodies in a patient with type 2 diabetes with immunological insulin resistance

  • Mahito Asai

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-166-68-2454; fax: +81-166-68-2459
    • ,
  • Tutomu Kodera

      Affiliations

    • The Third Department of Internal Medicine, National Defense Medical College, 359-8510 Saitama, Japan
    • ,
  • Kanaki Ishizeki

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • ,
  • Seiji Uebori

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • ,
  • Tagui Kashiwaya

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • ,
  • Hiroshi Itoh

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • ,
  • Isao Makino

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan

Received 25 November 2002 ,Revised 27 January 2003 ,Accepted 11 April 2003.

References 

  1. Bakaysa DL, Radziuk J, Havel HA, et al.  Physicochemical basis for the rapid time-action of LysB28 ProB29-insulin: dissociation of a protein–ligand complex. Protein Science. 1996;5:2521–2531
  2. Fineberg NS, Fineberg SE, Anderson JH, Birkett MA, Gibson RG, Hufferd S. Immunologic effects of insulin lispro [Lys (B28), Pro (B29) human insulin] in IDDM and NIDDM patients previously treated with insulin. Diabetes. 1996;45:1750–1754
  3. Jovanovic L, Ilic S, Pettitt DJ, et al.  Metabolic and immunologic effects of insulin lispro in gestational diabetes. Diabetes Care. 1999;22:1422–1427
  4. Lahatela JT, Knip M, Paul R, Antonen J, Salmi J. Severe antibody-mediated human insulin resistance: successful treatment with the insulin analog lispro. Diabetes Care. 1997;20:71–73
  5. Kumar D. Lispro analog for treatment of generalized allergy to human insulin. Diabetes Care. 1997;20:1357–1359
  6. Plank J, Semlitsch B, Wutte A, et al.  A direct comparison of insulin aspart and insulin lispro in patients with type 1 diabetes. Diabetes Care. 2002;25:2053–2057

PII: S0168-8227(03)00105-0

doi: 10.1016/S0168-8227(03)00105-0

Diabetes Research and Clinical Practice
Volume 61, Issue 2 , Pages 89-92 , August 2003

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