Diabetes Research and Clinical Practice
Volume 61, Issue 2 , Pages 89-92, August 2003

Insulin lispro reduces insulin antibodies in a patient with type 2 diabetes with immunological insulin resistance

  • Mahito Asai

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-166-68-2454; fax: +81-166-68-2459
    • ,
  • Tutomu Kodera

      Affiliations

    • The Third Department of Internal Medicine, National Defense Medical College, 359-8510 Saitama, Japan
    • ,
  • Kanaki Ishizeki

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • ,
  • Seiji Uebori

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • ,
  • Tagui Kashiwaya

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • ,
  • Hiroshi Itoh

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan
    • ,
  • Isao Makino

      Affiliations

    • The Second Department of Internal Medicine, Asahikawa Medical College, 078-8510 Hokkaido, Japan

Received 25 November 2002; received in revised form 27 January 2003; accepted 11 April 2003.

Abstract 

We describe a 54-year-old Japanese female with type 2 diabetes admitted to our hospital with poor metabolic control. On admission the patient's HbA1c was 9.1% despite having taken over 60 U of human insulin per day for the previous 10 years. A high titer of antibodies to insulin was detected in the serum, and therefore, we decided to introduce insulin lispro with the aim of minimizing immunogenicity. Over the next 2 months, the dosage of insulin required to achieve reasonable blood glucose control was reduced, with the HbA1c level decreasing significantly to 6.8%. The patient was subsequently withdrawn from insulin and discharged on diet therapy only. This case demonstrates that insulin lispro may ameliorate resistance to insulin therapy even in the presence of human insulin antibodies.

Keywords: Insulin lispro, Insulin antibodies, Immunological insulin resistance

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PII: S0168-8227(03)00105-0

doi:10.1016/S0168-8227(03)00105-0

Diabetes Research and Clinical Practice
Volume 61, Issue 2 , Pages 89-92, August 2003

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