Clinical features of diabetes mellitus with the mitochondrial DNA 3243 (A–G) mutation in Japanese: Maternal inheritance and mitochondria-related complications

Abstract 

Diabetes mellitus with the mitochondrial DNA 3243(A–G) mutation is reported to represent 0.5–2.8% of the general diabetic population. Since the characterization of diabetes with the mutation is still incomplete, we undertook a nation-wide case-finding study of genetically defined patients using questionnaires in Japan. One hundred and thirteen Japanese diabetic patients with the mutation were registered and analyzed. The patients had a high prevalence of maternal inheritance of diabetes and deafness, short and thin stature, and showed an early middle-aged onset of diabetes and deafness. Eighty-six percent of the patients required insulin therapy due to the progressive insulin secretory defect. Glucose intolerance of the mothers was associated with an early middle-aged onset of diabetes, reduction in the insulin secretory capacity, early requirement of insulin therapy, and increases in the daily insulin dose. The heteroplasmic concentrations of the 3243 mutation in leukocytes were low and declined with aging. The patients had advanced microvascular complications, and mitochondria-related complications such as cardiomyopathy, cardiac conductance disorders, neuromuscular symptoms, neuropsychiatric disturbance, and macular pattern dystrophy. Thus, this study has revealed that: (1) diabetes mellitus with the 3243 mutation is a subtype of diabetes mellitus with mitochondria-related complications; and (2) insulin secretory ability is more severely impaired in the patients whose mothers were glucose intolerance.

Keywords:  Mitochondrial DNA, Diabetes mellitus, Insulin, Deafness, Mitochondrial encephalomyopathy, Wolff–Parkinson–White syndrome, Sick sinus syndrome, Diabetic neuropathy, Diabetic retinopathy, Diabetic nephropathy

Abbreviations:  MIDD, maternally inherited diabetes mellitus and deafness, GAD, glutamic acid decarboxylase, MODY, maturity-onset diabetes of the young, MELAS, mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes, JDS, Japan Diabetes Society, IDDM, insulin-dependent diabetes, NIDDM, non-insulin-dependent diabetes, WPW, Wolff–Parkinson–White syndrome, IGT, impaired glucose tolerance, NGT, normal glucose tolerance