Diabetes Research and Clinical Practice
Volume 59, Issue 3 , Pages 219-224 , March 2003

Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients

  • Isamu Yamamoto

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Junko Fujitsu

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Shinpei Nohnen

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • ,
  • Tsuyoshi Igarashi

      Affiliations

    • Second Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan
    • ,
  • Takashi Motomura

      Affiliations

    • Second Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan
    • ,
  • Makiko Inaba

      Affiliations

    • Second Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan
    • ,
  • Shoji Tsubakimori

      Affiliations

    • Laboratory of Clinical Medicine, NTT West Osaka Hospital, Osaka, Japan
    • ,
  • Junichi Azuma

      Affiliations

    • Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-6-6879-8258; fax: +81-6-6879-8259

Received 5 June 2002 ,Revised 17 September 2002 ,Accepted 17 October 2002.

References 

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  2. Miwa M, Miyake T, Yamanaka T, et al.  Characterization of serum platelet-activating factor (PAF) acetylhydrolase. J. Clin. Invest. 1988;82:1983–1991
  3. Stafforini DM, Satoh K, Atkinson DL, et al.  Platelet-activating factor acetylhydrolase deficiency. J. Clin. Invest. 1996;97:2784–2791
  4. Yamada Y, Ichihara S, Fujimura T, Yokota M. Identification of the G994 T missense mutation in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men. Metabolism. 1997;47:177–181
  5. Hiramoto M, Yoshida H, Imaizumi T, Yoshimizu N, Satoh K. A mutation in plasma platelet-activating factor acetylhydrolase is a genetic risk factor for stroke. Stroke. 1997;28:2417–2420
  6. Uno N, Nakamura T, Kaneko H, et al.  Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in Japan. J. Vasc. Surg. 2000;32:263–267
  7. Uno N, Nakamura T, Mitsuoka H, et al.  Association of a G994T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. Ann. Surg. 2002;235:297–302
  8. Quarck R, Geest BD, Stengel D, et al.  Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2001;103:2495–2500
  9. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation. 1986;74:1399–1406
  10. Yamazaki Y, Kawamori R, Matsushima H, et al.  Atherosclerosis in carotid artery of young IDDM patients monitored by ultrasound high-resolution B-mode imaging. Diabetes. 1994;43:634–639
  11. Kosaka T, Yamaguchi M, Soda Y, et al.  Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. Clin. Chim. Acta. 2000;296:151–161
  12. The Suita Study Mannami T, Konishi M, Baba S, Nishi N, Terao A. Prevalence of asymptomatic carotid atherosclerotic lesions detected by high-resolution ultrasonography and its relation to cardiovascular risk factor in the general population of a Japanese city. Stroke. 1997;28:518–525
  13. Yamada Y, Yoshida H, Ichihara S, Imaizumi T, Satoh K, Yokota M. Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. Atherosclerosis. 2000;150:209–216

PII: S0168-8227(02)00245-0

Diabetes Research and Clinical Practice
Volume 59, Issue 3 , Pages 219-224 , March 2003

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