Diabetes Research and Clinical Practice
Volume 58, Issue 3 , Pages 179-185 , December 2002

Endothelial nitric oxide synthase gene and the development of diabetic nephropathy

  • Tomoaki Shimizu

      Affiliations

    • Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Hongo 3-1-1, Bunkyo, Zip# 113-8421 Tokyo, Japan
    • ,
  • Tomio Onuma

      Affiliations

    • Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Hongo 3-1-1, Bunkyo, Zip# 113-8421 Tokyo, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-3-3813-3111x3560; fax: +81-3-3813-5996
    • ,
  • Ryuzo Kawamori

      Affiliations

    • Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Hongo 3-1-1, Bunkyo, Zip# 113-8421 Tokyo, Japan
    • ,
  • Yuichiro Makita

      Affiliations

    • Department of Medicine, Divison of Nephrology, Juntendo University School of Medicine, Hongo 3-1-1, Bukyo, Tokyo, Japan
    • ,
  • Yasuhiko Tomino

      Affiliations

    • Department of Medicine, Divison of Nephrology, Juntendo University School of Medicine, Hongo 3-1-1, Bukyo, Tokyo, Japan

Received 3 October 2001 ,Revised 8 May 2002 ,Accepted 17 June 2002.

References 

  1. A.S. Kolewski, J.H. Warram, Christlieb et al., The changing natural history of nephropathy in type 1 dibetes, Am. J. Med. 78 (1985) 785–794.
  2. Andersen AR, Christiansen PK, Andersen JK, et al.  T: Diabetic nephropathy in IDDM diabetes, an epidemiological study. Diabetologia. 1983;25:496–501
  3. Krolewski AS, Warram JH, Christlieb AR, et al.  Epidemiological approach to studies on etiology of IDDM and its complications. N. Engl. J. Med. 1987;317:140–145
  4. Seaquist ER, Goetz FC, Rich S, Barbosa J. Familiar clustering of diabetic nephropathy. N. Engl. J. Med. 1989;320:1161–1165
  5. Pettitt DJ, Saad MF, Bennett PM, et al.  Familiar predisposition to renal disease in two generations of Pima Indians with type 2 non-insulin dependent diabetes mellitus. Diabetologia. 1990;33:438–440
  6. Quinn M, Angelico MC, Warram JH, Krolewski AS. Familial factors determine the development of diabetic nephropathy in patients with IDDM. Diabetologia. 1996;39(8):940–945
  7. Tsukada T, Yokoyama K, Arai T, et al.  Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Bicchem. Biophys. Res. Commun. 1998;245:190–193
  8. Simmons JI, Provoost AP, Anderson S, et al.  Modulation of glomerulohypertension defines susceptibility to progressive glomerular injury. Kidney Int. 1994;46:396–404
  9. Tolins P, Shults PJ, Raij L, et al.  Abnormal renal hemodynamic response to reduced renal perfusion pressure in diabetic rats: role of NO. Am. J. Physiol. 1993;265:F886–F895
  10. Kone BC, Baylis C. Biosynthesis and homeostatic roles of nitric oxide in the normal kidney. Am. J. Physiol. 1997;272:F561–F578
  11. Raij L, Baylis C. Glomerular actions of nitric oxide. Kidney Int. 1995;48:20–23
  12. Komers R, Allen TJ, Cooper ME. Role of endothelium-derived nitric oxide in the pathogenesis of the renal hemodynamic changes of experimental diabetes. Diabetes. 1994;43:1190–1194
  13. Sugimoto H, Shikata K, Matsuda M, et al.  Increased expression of endothelial cell nitric oxide synthase in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy. Diabetologia. 1998;41:1426–1434
  14. Chiarlli F, Cipllone F, Romano F, et al.  Increased circulating nitric oxide in young patients with type 1 diabeties and persistent microalubuminuria (relation to glomerular hyperfiltration). Diabetes. 2000;49:1258–1263
  15. Bank N, Aynedjian HS. Role of EDRF in diabetic renal hyperfiltration. Kidney Int. 1993;43:1306–1312
  16. Reyes AA, Karl IE, Kissance J, Klahr S. l-arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats. J. Am. Soc. Nephrol. 1993;4:1039–1045
  17. Corbett JA, Tilton RG, Chang K, et al.  Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction. Diabetes. 1992;41:552–556
  18. Cosentino F, Hishikawa K, Katusic ZS, Luscher T. High glucose increases nitric oxide syntase expression and superoxide anion generation in human aortic endothelial cells. Circulation. 1997;96:25–28
  19. Zanchi A, Moczulski DK, Hanna LS, et al.  Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism. Kidney Int. 2000;57:405–413
  20. Neugebauer S, Tsuneharu B, Tsuyoshi W. Association of the nitric oxide synthase gene polymorphism with an increased risk for development to diabetic nephropathy in type 2 diabetes. Diabetes. 2000;49(3):500–503
  21. Fujita H, Narita T, Meguro H, et al.  Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. Horm. Metab. Res. 2000;32:80–83
  22. Nadaud S, Bonnardeaux A, Lathrop M, Soubrier F. Gene structure polymorphism and mapping of the human endothelial nitric oxide syntase gene. Biochem. Res. Commun. 1994;198:1027–1033
  23. Marsden PA, Heng HH, Scherer SW, et al.  Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J. Biol. Chem. 1993;268:17 478–17 488
  24. Miyahara K, Kawamoto T, Sase K, et al.  Cloning and structural characterization of the human endothelial nitric oxide synthase gene. Eur. J. Biochem. 1994;223:719–726
  25. Wang XL, Sim AS, Badenhop RF, et al.  A smoking dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat. Med. 1996;2:41–45
  26. Borch JK, Anderson PK, Deckert T. The effect of proteinuria on relative mortality in insulin dependent diabetes (an epidemiological study). Diabetologia. 1983;25:496–501

PII: S0168-8227(02)00156-0

Diabetes Research and Clinical Practice
Volume 58, Issue 3 , Pages 179-185 , December 2002

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