Diabetes Research and Clinical Practice
Volume 56, Issue 3 , Pages 221-227, June 2002

Type of diabetes and waist–hip ratio are important determinants of serum lipoprotein (a) levels in diabetic patients

  • Hapizah M. Nawawi

      Affiliations

    • Chemical Pathology Unit, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia
    • Corresponding Author InformationCorresponding author. Tel.: +60-3-9170-2276; fax: +60-3-9173-8255
    • ,
  • Musilawati Muhajir

      Affiliations

    • Chemical Pathology Unit, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Yeo Chee Kian

      Affiliations

    • Chemical Pathology Unit, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Wan Nazaimoon Wan Mohamud

      Affiliations

    • Institute of Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia
    • ,
  • Khalid Yusoff

      Affiliations

    • Chemical Pathology Unit, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • B.A.K. Khalid

      Affiliations

    • Chemical Pathology Unit, Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur, Malaysia

Accepted 7 January 2002.

Abstract 

This cross-sectional study compared serum lipoprotein (a) [Lp(a)] concentrations in type 1 and type 2 diabetic subjects and examined the determinants of Lp(a) concentrations in both types of diabetes. Serum Lp(a) was measured in 26 type 1 and 107 type 2 diabetic patients and 126 non-diabetic controls. HbA1c, fasting lipids and urinary albumin were also assayed. Lp(a) concentrations were higher in both type 1 and type 2 diabetic patients compared with controls (P<0.0001 and P<0.0001, respectively), and were higher in type 1 than type 2 diabetic patients (P<0.05). Waist–hip ratio (WHR) was an independent determinant of Lp(a) concentrations in both type 1 and type 2 diabetes.

Keywords:  Lipoprotein (a), Diabetes, Waist–hip ratio

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PII: S0168-8227(02)00009-8

Diabetes Research and Clinical Practice
Volume 56, Issue 3 , Pages 221-227, June 2002

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