Diabetes Research and Clinical Practice
Volume 56, Issue 3 , Pages 181-187 , June 2002

Low lipoprotein lipase mass in preheparin serum of type 2 diabetes mellitus patients and its recovery with insulin therapy

  • Yoh Miyashita

      Affiliations

    • Department of Internal Medicine, Sakura Hospital, School of Medicine, Toho University, 564-1 Shimoshizu, Sakura-City, Chiba 285-0841, Japan
    • Clinical Laboratory Medicine, Sakura Hospital, School of Medicine, Toho University, 564-1 Shimoshizu, Sakura-City, Chiba 285-0841, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-43-462-8811; fax: +81-43-489-9770
    • ,
  • Kohji Shirai

      Affiliations

    • Department of Pharmacy, Sakura Hospital, School of Medicine, Toho University, 564-1 Shimoshizu, Sakura-City, Chiba 285-0841, Japan
    • ,
  • Yoshiaki Itoh

      Affiliations

    • Department of Internal Medicine, Sakura Hospital, School of Medicine, Toho University, 564-1 Shimoshizu, Sakura-City, Chiba 285-0841, Japan
    • ,
  • Hidehisa Sasaki

      Affiliations

    • Department of Pharmacy, Sakura Hospital, School of Medicine, Toho University, 564-1 Shimoshizu, Sakura-City, Chiba 285-0841, Japan
    • ,
  • Mitsuya Totsuka

      Affiliations

    • Department of Internal Medicine, Sakura Hospital, School of Medicine, Toho University, 564-1 Shimoshizu, Sakura-City, Chiba 285-0841, Japan
    • ,
  • Takeyoshi Murano

      Affiliations

    • Department of Pharmacy, Sakura Hospital, School of Medicine, Toho University, 564-1 Shimoshizu, Sakura-City, Chiba 285-0841, Japan
    • ,
  • Hitoshi Watanabe

      Affiliations

    • Department of Pharmacy, Sakura Hospital, School of Medicine, Toho University, 564-1 Shimoshizu, Sakura-City, Chiba 285-0841, Japan

Received 29 July 2001 ,Revised 2 October 2001 ,Accepted 26 November 2001.

References 

  1. Nilsson-Ehle PA, Garfinkel AS, Schotz MC. Lipolytic enzymes and plasma lipoprotein metabolism. Annu. Rev. Biochem. 1980;49:667–693
  2. Louis CS, Henry JP. In: Lipoprotein Lipase, Lipases. Amsterdam: Elsever; 1984;p. 263–305
  3. Braun JEA, Severson DL. Regulation of the synthesis, processing and translocation of lipoprotein lipase. Biochem. J. 1992;287:337–347
  4. Sexena U, Klein MG, Goldberg IJ. Transport of lipoprotein lipase across endothelial cells. Proc. Natl. Acad. Sci. USA. 1991;88:2254–2258
  5. Sexena U, Wit LAD, Goldberg IJ. Release of endothelial cell lipoprotein lipase by plasma lipoproteins and free fatty acid. J. Boil. Hem. 1982;264:4349–4355
  6. Peterson J, Bihain BE, Bengtsson-Olivecrona G, Deckelbaum RJ, Carpentier YA, Olivecrona T. Fatty acid control of lipoprotein lipase, a link between energy metabolism and lipid transport. Proc. Natl. Acad. Sci. USA. 1990;87:909–913
  7. Kobayashi J, Hashimoto H, Fukamachi I, Tashiro J, Shirai K, Saito Y, et al. Lipoprotein lipase mass and activity in severe hypertriglyceridemia. Clin. Chem. Acta. 1993;216:113–123
  8. Tornvall P, Olivecrona G, Carpe F, Andres H, Olivecrona T. Lipoprotein lipase mass and activity in plasma and there increase after heparin are separate parameters with different relations to plasma lipoproteins. Arterioscler. Thromb. Vasc. Biol. 1995;15:1086–1093
  9. Watanabe H, Shirai K, Murano T, Hiroh Y, Itoh Y, Miyashita Y. Preheparin serum lipoprotien lipase mass level: The effects of age, gender, and types of hyperlipidemias. Atherosclerosis. 1999;145:45–50
  10. Shirai K, Itoh I, Sasaki H, Totsuka M, Murano T, Watanabe H, et al. The effect of insulin sensitizer troglitazone, on lipoprotein lipase mass in preheparin serum. Diabetes Res. Clin. Pract. 1999;46:35–41
  11. Cavaghan MK, Ehrmann DA, Byrne MM, Polonsky KS. Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance. J. Clin. Invest. 1997;100:530–537
  12. Suter SL, Nolan JJ, Wallace P, Gumbiner B, Ollefsky JM. Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care. 1992;15:223–233
  13. Ong JM, Kirchgessner TG, Schotz MC, Kern PA. Insulin increases the synthetic rate and messenger RNA level of lipoprotein lipase in isolated rat adipocyte. J. Biol. Chem. 1988;263:12 933–12 938
  14. Semenkovich CF, Wims M, Noe L, Chan L. Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels. J. Biol. Chem. 1989;264:9030–9038
  15. Shirai K, Nema T, Hiroh Y, Itoh Y, Miyashita Y, Watanabe H. Clinical efficacy of the direct assay method using polymers for serum high density lipoprotein cholesterols. J. Clin. Lab. Anal. 1992;11:82–86
  16. Nikkila EA, Huttunen JK, Ehnholm C. Postheparin plasma lipoprotein lipase and hepatic lipase in diabetic mellitus: relationship to plasma triglyceride metabolism. Diabetes. 1977;26:11–21

PII: S0168-8227(01)00369-2

Diabetes Research and Clinical Practice
Volume 56, Issue 3 , Pages 181-187 , June 2002

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