Diabetes Research and Clinical Practice
Volume 56, Issue 2 , Pages 107-113 , May 2002

First human trial of pancreatic islet allo-transplantation in Korea—focus on re-transplantation

  • Tae-Young Yang

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Seung Hoon Oh

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • In-Kyung Jeong

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • In Ah Seo

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Eun Young Oh

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Sung-Joo Kim

      Affiliations

    • Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Jae Hoon Chung

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Yong-Ki Min

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Myung-Shik Lee

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Moon-Kyu Lee

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Kwang-Won Kim

      Affiliations

    • Department of Medicine, Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82-2-3410-3444; fax: +82-2-3410-3848
    • ,
  • Young Soo Do

      Affiliations

    • Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea
    • ,
  • Sung Wook Choo

      Affiliations

    • Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea

Received 9 August 2001 ,Revised 26 September 2001 ,Accepted 2 November 2001.

References 

  1. Alejandro R, Lehmann R, Ricordi C, Kenyon NS, Angelico MC, Burke G, et al. Long-term function (6 years) of islet allografts in type 1 diabetes. Diabetes. 1997;46:1983–1989
  2. Harris MI, Eastman RC, Siebert C. The DCCT and medical care for diabetes in the US. Diabetes Care. 1994;17:761–764
  3. Sutherland DE. Pancreas and islet transplantation. II. Clinical trials. Diabetologia. 1981;20:435–450
  4. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. New Engl. J. Med. 2000;343:230–238 see comments
  5. Bertuzzi F, Secchi A, Aldrighetti L, Nano R, Pozza G, Di Carlo V. Islet transplantation in diabetic patients. J. Pediatr. Endocrinol. Metab. 1999;12:771–775
  6. ITR Newsletter No. 8 on the Seventh World Congress of the IPITA, Sydney, August, 1999.
  7. Bretzel RG, Brandhorst D, Brandhorst H, Eckhard M, Ernst W, Friemann S, et al. Improved survival of intraportal pancreatic islet cell allografts in patients with type-1 diabetes mellitus by refined peritransplant management. J. Mol. Med. 1999;77:140–143
  8. Ricordi C, Lacy PE, Scharp DW. Automated islet isolation from human pancreas. Diabetes. 1989;38(Suppl. 1):140–142
  9. Berney T, Ricordi C. Islet transplantation. Cell Transplant. 1999;8:461–464
  10. Bertuzzi F, Garancini P, Socci TC, Nano R, Taglietti MV, Santopinto M, et al. Lessons from in vitro perifusion of pancreatic islets isolated from 80 human pancreases. Cell Transplant. 1999;8:709–712
  11. Hussain MA. CD154 for the dragon: a promising development for pancreatic islet transplantation and cure for type 1 diabetes mellitus. Eur. J. Endocrinol. 2000;142:111–113
  12. Friedman T, Smith RN, Colvin RB, Iacomini J. A critical role for human CD4+ T-cells in rejection of porcine islet cell xenografts. Diabetes. 1999;48:2340–2348
  13. Lalain S, Chaillous L, Gouin E, Sai P. Intensity and mechanisms of in vitro xenorecognition of adult pig pancreatic islet cells by CD4+ and CD8+ lymphocytes from type I diabetic or healthy subjects. Diabetologia. 1999;42:330–335
  14. Oberholzer J, Triponez F, Mage R, Andereggen E, Buhler L, Cretin N, et al. Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations. Transplantation. 2000;69:1115–1123
  15. Rabkin JM, Olyaei AJ, Orloff SL, Geisler SM, Wahoff DC, Hering BJ, et al. Distant processing of pancreas islets for autotransplantation following total pancreatectomy. Am. J. Surg. 1999;177:423–427
  16. Oberholzer J, Triponez F, Lou J, Morel P. Clinical islet transplantation: a review. Ann. N.Y. Acad. Sci. 1999;875:189–199
  17. Federlin K, Pozza G. Indications for clinical islet transplantation today and in the foreseeable future—the diabetologist's point of view. J. Mol. Med. 1999;77:148–152
  18. Eckhoff DE, McGuire B, Sellers M, Contreras J, Frenette L, Young C, et al. The safety and efficacy of a two-dose daclizumab (Zenapax) induction therapy in liver transplant recipients. Transplantation. 2000;69:1867–1872
  19. Johansson BL, Borg K, Fernqvist-Forbes E, Odergren T, Remahl S, Wahren J. C-peptide improves autonomic nerve function in IDDM patients. Diabetologia. 1996;39:687–695
  20. Paraskevas S, Maysinger D, Wang R, Duguid TP, Rosenberg L. Cell loss in isolated human islets occurs by apoptosis. Pancreas. 2000;20:270–276

PII: S0168-8227(01)00366-7

Diabetes Research and Clinical Practice
Volume 56, Issue 2 , Pages 107-113 , May 2002

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