Diabetes Research and Clinical Practice
Volume 56, Issue 2 , Pages 93-99 , May 2002

Tumor necrosis factor system in insulin resistance in gestational diabetes

  • Gábor Winkler

      Affiliations

    • Second Department of Internal Medicine, St. John's Hospital, H-1125, Diós Árok 1, Budapest, Hungary
    • Corresponding Author InformationCorresponding author. Tel.: +36-1-458-4539; fax: +36-1-458-4667
    • This author contributed equally to this work.
    • ,
  • Károly Cseh

      Affiliations

    • First Department of Internal Medicine, Károlyi Hospital, Budapest, Hungary
    • This author contributed equally to this work.
    • ,
  • Éva Baranyi

      Affiliations

    • Diabetes Care Outpatient Unit, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary
    • ,
  • Zsolt Melczer

      Affiliations

    • Second Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweiss University, Budapest, Hungary
    • ,
  • Gábor Speer

      Affiliations

    • First Department of Medicine, Faculty of Medicine, Semmelweiss University, Budapest, Hungary
    • ,
  • Péter Hajós

      Affiliations

    • Second Department of Internal Medicine, St. John's Hospital, H-1125, Diós Árok 1, Budapest, Hungary
    • ,
  • Ferenc Salamon

      Affiliations

    • Second Department of Internal Medicine, St. John's Hospital, H-1125, Diós Árok 1, Budapest, Hungary
    • ,
  • Zsuzsa Turi

      Affiliations

    • Diabetes Care Outpatient Unit, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary
    • ,
  • Margit Kovács

      Affiliations

    • Third Department of Medicine Faculty of Medicine, Semmelweiss University, Budapest, Hungary
    • ,
  • Péter Vargha

      Affiliations

    • First Department of Medicine, Faculty of Medicine, Semmelweiss University, Budapest, Hungary
    • ,
  • István Karádi

      Affiliations

    • Third Department of Medicine Faculty of Medicine, Semmelweiss University, Budapest, Hungary

Received 20 June 2001 ,Revised 9 October 2001 ,Accepted 30 October 2001.

References 

  1. Zoupas C. Gestational diabetes mellitus. Diabetes Rev. Int. 1995;4(4-5):5–7
  2. Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EAH. Longitudinal changes in insulin release and insulin resistance in non-obese pregnant women. Am. J. Obstet. Gynecol. 1991;165:1667–1672
  3. Buchanan TA, Metzger BE, Freinkel N, Berman RN. Insulin sensitivity and beta-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am. J. Obstet. Gynecol. 1990;162:1008–1014
  4. Hotamisligil GS, Spiegelman BM. Tumor necrosis factor-alfa—a key component of the obesity—diabetes link. Diabetes. 1994;43:1271–1278
  5. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. J. Clin. Invest. 1995;95:2111–2119
  6. Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. The expression of TNF-α by human muscle: relationship to insulin resistance. J. Clin. Invest. 1996;97:1111–1116
  7. Liu LS, Spelleken M, Röhrig K, Hauner H, Eckel J. Tumor necrosis factor-α acutely inhibits insulin signaling in human adipocytes. Implication of the p80 tumor necrosis factor receptor. Diabetes. 1998;47:515–522
  8. Winkler G, Salamon F, Harmos G, Salamon D, Speer G, Szekeres O, et al.  Elevated serum tumor necrosis factor-alpha concentrations and bioactivity in Type 2 diabetics and patients with android type obesity. Diabetes Res. Clin. Pract. 1998;42:169–174
  9. Winkler G, Lakatos P, Salamon F, Nagy Zs, Speer G, Kovács M, et al.  Elevated serum TNF-α as a link between endothelial dysfunction and insulin resistance in normotensive obese patients. Diabetic Med. 1999;16:207–211
  10. Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO Consultation. World Health Organization, WHO/NCD/NCS 99.2, Geneva, 1999.
  11. Fernandez-Real JM, Broch M, Ricart W, Casamitjana R, Gutierrez C, Vendrell J, et al.  Plasma levels of soluble fraction of tumor necrosis factor receptor-2 and insulin resistance. Diabetes. 1998;47:1757–1762
  12. Blüher M, Kratzsch J, Paschke R. Plasma levels of tumor necrosis factor-α, angiotensin II, growth hormone and IGF-I are not elevated in insulin-resistant obese individuals with impaired glucose tolerance. Diabetes Care. 2001;24:328–334
  13. Hotamisligil GS. Mechanisms of TNF-α-induced insulin resistance. Exp. Clin. Endocrinol. Diabetes. 1999;107:119–125
  14. Cheung AT, Ree D, Kolls JK, Fuselier J, Coy DH, Bryer-Ash M. An in vivo model for elucidation of the mechanism of TNF α induced insulin resistance: evidence for differential regulation of insulin signaling by TNF α. Endocrinology. 1998;139:4928–4935
  15. Drenth JP, Krebbers RJ, Bijzet J, van der Meer JW. Increased circulating cytokine receptors and ex vivo interleukin-1 beta production but decreased tumour necrosis factor-alpha production after a 5-km run. Eur. J. Clin. Invest. 1998;28:866–872
  16. Fernandez-Real JM, Gutierrez C, Vendrell J, Casamitjana R, Ricart W. Plasma soluble tumor necrosis factor-alpha receptors circulate in proportion to leptin levels during the menstrual cycle in lean but not in obese women. Eur. J. Endocrinol. 2000;143:235–241
  17. Williams MA, Farrand A, Mittendorf R, Sorensen TK, Singheim RW, O'Rahilly GC, et al.  Maternal second trimester serum tumor necrosis factor-alpha soluble receptor p55 (sTNF p55) and subsequent risk of preeclampsia. Am. J. Epidemiol. 1999;149:323–329
  18. Steinborn A, Niederhut A, Solbach C, Hildebrand R, Sohn C, Kaufmann M. Cytokine release from placental endothelial cells, a process associated with preterm labour in the absence of intrauterine infection. Cytokine. 1999;11:66–73
  19. Kruse N, Greif M, Moriabadi NF, Marx L, Toyka KV, Rieckman P. Variations in cytokine mRNA expression during normal human pregnancy. Clin. Exp. Immunol. 2000;119:317–322

PII: S0168-8227(01)00355-2

Diabetes Research and Clinical Practice
Volume 56, Issue 2 , Pages 93-99 , May 2002

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