Diabetes Research and Clinical Practice
Volume 55, Issue 1 , Pages 1-9 , January 2002

Antibodies to food antigens in Japanese patients with type 1 diabetes mellitus

  • Takeyuki Kohno

      Affiliations

    • Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-72-8663113; fax: +81-72-8507020
    • ,
  • Yasuyuki Kobashiri

      Affiliations

    • Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan
    • ,
  • Yohko Sugie

      Affiliations

    • Laboratory of Diagnostics, Research Institute for Production Development, 15 Simogamo-Morimoto-cho, Sakyo-Ku, Kyoto 606-0805, Japan
    • ,
  • Shigehisa Takai

      Affiliations

    • Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan
    • ,
  • Kazuhito Watabe

      Affiliations

    • Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan
    • ,
  • Yukikazu Kaino

      Affiliations

    • Department of Pediatrics, Ehime University School of Medicine, Shigenobu, Ehime 791-0295, Japan
    • ,
  • Kaichi Kida

      Affiliations

    • Department of Pediatrics, Ehime University School of Medicine, Shigenobu, Ehime 791-0295, Japan

Received 2 September 2000 ,Revised 18 January 2001 ,Accepted 28 February 2001.

References 

  1. Gepts W. Pathogenic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes. 1965;14:619–633
  2. Bottazzo GF, Florin-Christensen A, Doniach D. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974;2(7892):1279–1283
  3. Lernmark A, Freesman ZR, Hofman C, et al.  Islet-cell-surface antibodies in juvenile diabetes mellitus. New Engl. J. Med. 1978;299:375–380
  4. Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of death in patients under 20 years of age in the UK. Diabetologia. 1986;29:267–274
  5. Eisenbarth GS. Type 1 diabetes mellitus. A chronic autoimmune disease. New Engl. J. Med. 1986;314:1360–1368
  6. Todd JA, Bell JI, McDevitt HO. HLA-DQ β gene contributes susceptibility and resistance to IDDM. Nature. 1987;329:599–604
  7. Thomson G, Robinson WP, Kuhner MK. Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with IDDM. Am. J. Hum. Genet. 1988;43:799–816
  8. Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M. Aspartic acid at position 57 of the HLA-Dβ chain protects against type 1 diabetes: a family study. Proc. Natl. Acad. Sci. USA. 1988;85:8111–8115
  9. Olmos P, A'Hern R, Heaton DA, et al.  The significance of the concordance rate for type 1 diabetes in identical twins. Diabetologia. 1988;31:747–750
  10. Castano L, Eisenbarth GS. Type 1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu. Rev. Immunol. 1990;8:747–779
  11. Baish JM, Weeks T, Giles R, Hoover M, Stasny P, Capra JD. Analysis of HLA-DQ genotypes and susceptibility in IDDM. New Engl. J. Med. 1990;322:1836–1841
  12. Todd JA. A protective role of the environment in the development of type 1 diabetes. Diabetes Med. 1991;8:906–910
  13. Solimena M, De Camilli P. Coxsackievirus and diabetes. Nat. Med. 1995;1:25–26
  14. Borch-Johnsen K, Joner G, Mandrup-Poulsen T, et al.  Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus. A hypothesis. Lancet. 1984;2(8411):1083–1086
  15. Gerstein HC. Cow's milk exposure and type 1 diabetes mellitus. A critical overview of the clinical literature. Diabetes Care. 1994;17:13–19
  16. Fava D, Leslie RD, Pozzilll P. Relation between diary product consumption and incidence of IDDM in childhood in Italy. Diabetes Care. 1994;17:1488–1490
  17. Virtanen SV, Räsänen L, Ylänen K, Aro A, Clayton D, Langholz B, et al.  Early introduction of dairy products associated with increased risk of IDDM in Finnish children. Diabetes. 1993;42:1786–1790
  18. Ellis TM, Atkinson MA. Early infant diets and insulin-dependent diabetes. Lancet. 1996;347:1464–1465
  19. Vähäsalo P, Petays T, Knip M, et al.  Relation between antibodies to islet cell antigens, other autoantigens and cow's milk proteins in diabetic children and unaffected siblings at the clinical manifestation of IDDM. Autoimmunity. 1996;23:165–174
  20. Saukkonen T, Virtanen SM, Karppinen M, et al.  Significance of cow's milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow's milk intake and HLA-DQB1 genotype. Diabetologia. 1998;41:72–78
  21. Karjalainen J, Martin JM, Knip M, et al.  A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. New Engl. J. Med. 1992;327:302–307
  22. Savilahti E, Saukkonen T, Virtala ET, Tuomilehto J, Åkerblom HK. The Childhood Diabetes in Finland Study Group, increased levels of cow's milk and β-lactoglobulin antibodies in young children with newly diagnosed IDDM. Diabetes Care. 1993;16:984–989
  23. Saukkonen T, Savilahti E, Vaarala O, et al.  Children with newly diagnosed IDDM have increased levels of antibodies to bovine serum albumin but not to ovalbumin. Diabetes Care. 1994;17:970–976
  24. Cavallo MG, Fava D, Monetini L, Barone F, Pozzilli P. Cell-mediated immune response to β casein in recent-onset insulin-dependent diabetes: implications for disease pathogenesis. Lancet. 1996;348:926–928
  25. Anmed T, Kamota T, Sumazaki R, Shibasaki M, Hirano T, Takita H. Circulating antibodies to common food antigens in Japanese children with IDDM. Diabetes Care. 1997;20:74–76
  26. Atkinson MA, Bowman MS, Kao K-J, et al.  Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. New Engl. J. Med. 1993;329:1853–1858
  27. Saukkonen T, Savilahti E, Landin-Olson M, Dahlquist G. IgA bovine serum albumin antibodies are increased in newly diagnosed patients with insulin-dependent diabetes mellitus, but the increase is not an independent risk factor for diabetes. Acta Pediatr. 1995;84:1258–1261
  28. Noris JM, Beaty B, Klingensmith G, et al.  Lack of association between early exposure to cow's milk protein and β-cell autoimmunity. J. Am. Med. Assoc. 1996;276:609–614
  29. Vähäsalo P, Klemetti P, Savilahti E, Reijonen H, Ilonen J, Åkerblom HK. Cellular immune response to cow's milk β-lactoglobulin in patients with newly diagnoses IDDM. Diabetes. 1996;45:178–182
  30. Meloni T, Marinaro AM, Mannazzu MC, et al.  IDDM and early infant feeding. Sardinian case-control study. Diabetes Care. 1997;20:340–342
  31. Paxson JA, Weber JG, Kulczycki A. Cow's milk-free diet does not prevent diabetes in NOD mice. Diabetes. 1997;46:1711–1717
  32. Kaino Y, Kida K, Goto Y, et al.  Thyroglobulin antibodies in type 1 diabetic patients and their relatives-measurement with highly sensitive assay. Diabetes Res. Clin. Pract. 1994;22:147–154
  33. Berman MA, Sandborg CI, Wang Z, et al.  Decreased IL-4 production in new onset type 1 insulin-dependent diabetes mellitus. J. Immunol. 1996;157:4690–4696
  34. Ishikawa E, Kohno T. Development and applications of sensitive enzyme immunoassay for antibodies: a review. J. Clin. Lab. Anal. 1989;3:252–265

PII: S0168-8227(01)00250-9

Diabetes Research and Clinical Practice
Volume 55, Issue 1 , Pages 1-9 , January 2002

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