Diabetes Research and Clinical Practice
Volume 50, Issue 2 , Pages 147-152 , 1 October 2000

Age of onset, not type of onset, affects the positivity and evanescence of IA-2 antibody

  • Shinya Nakamoto

      Affiliations

    • Department of Internal Medicine, Mito Red Cross Hospital , 3-12-48, Sannomaru, Mito-city, Ibaraki 310-0011, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-29-2215177; fax: +81-29-2270819
    • ,
  • Akira Kasuga

      Affiliations

    • Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Taro Maruyama

      Affiliations

    • Department of Internal Medicine, Saitama Social Insurance Hospital, Urawa, Japan
    • ,
  • Yukako Ozawa

      Affiliations

    • Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Shin Amemiya

      Affiliations

    • Department of Pediatrics, Yamanashi Medical University, Kofu, Japan
    • ,
  • Takao Saruta

      Affiliations

    • Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Received 27 December 1999 ,Revised 11 April 2000 ,Accepted 28 April 2000.

References 

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  2. Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibody in diabetes mellitus with autoimmune polyendicrine deficiencies. Lancet. 1974;2:1279–1283
  3. Lendrum R, Walker G, Gamble DR. Islet-cell antibodies in juvenile diabetes mellitus of recent onset. Lancet. 1975;1:880–883
  4. Bonifacio E, Bingley PJ, Shattock M, et al.  Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet. 1990;335:147–149
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  7. Lu J, Li Q, Xie H, et al.  Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37 kDa tryptic fragment. Proc. Natl. Acad. Sci. USA. 1996;93:2307–2311
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  9. Lan MS, Lu J, Goto Y, Notkins AL. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol. 1994;13:505–514
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  11. Kasuga A, Ozawa Y, Maruyama T, Ishihara T, Amemiya S, Saruta T. Autoantibody against IA-2 improves the test sensitivity for insulin-dependent diabetes mellitus in Japanese patients of child onset. Endocr. J. 1997;44:485–491
  12. Kasuga A, Ozawa Y, Maruyama T, Ishihara T, Amemiya S, Saruta T. Autoantibody against ICA512 did not improve test sensitivity for slowly progressive IDDM in adults. Diabetes Care. 1997;20:679–680
  13. Falorni A, Ortqvist E, Persson B, Lernmark Å. Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands. J. Immunol. Methods. 1995;186:89–99
  14. Karlsen AE, Hagopian WA, Grubin CE, et al.  Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc. Natl. Acad. Sci. USA. 1991;88:8337–8341
  15. Verge CF, Gianani R, Kawasaki E, et al.  Prediction of type I diabetes mellitus in first degree relatives using a combination of insulin, glutamic acid decarboxylase and ICA512bdc/IA-2 autoantibodies. Diabetes. 1996;45:926–933
  16. Kasuga A, Maruyama T, Ozawa Y, et al.  Antibodies to the Mr 65 000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese. J. Autoimmun. 1996;9:101–115
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  19. Myers MA, Rabin DU, Rowley MJ. Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes. 1995;44:1290–1295

PII: S0168-8227(00)00168-6

Diabetes Research and Clinical Practice
Volume 50, Issue 2 , Pages 147-152 , 1 October 2000

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