Diabetes Research and Clinical Practice
Volume 50, Issue 2 , Pages 147-152, 1 October 2000

Age of onset, not type of onset, affects the positivity and evanescence of IA-2 antibody

  • Shinya Nakamoto

      Affiliations

    • Department of Internal Medicine, Mito Red Cross Hospital , 3-12-48, Sannomaru, Mito-city, Ibaraki 310-0011, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-29-2215177; fax: +81-29-2270819
    • ,
  • Akira Kasuga

      Affiliations

    • Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Taro Maruyama

      Affiliations

    • Department of Internal Medicine, Saitama Social Insurance Hospital, Urawa, Japan
    • ,
  • Yukako Ozawa

      Affiliations

    • Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    • ,
  • Shin Amemiya

      Affiliations

    • Department of Pediatrics, Yamanashi Medical University, Kofu, Japan
    • ,
  • Takao Saruta

      Affiliations

    • Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Received 27 December 1999; received in revised form 11 April 2000; accepted 28 April 2000.

Abstract 

Autoantibody against IA-2 (IA-2A) was found to be discordant with autoantibody against glutamic acid decarboxylase (GADA) with respect to both positivity and titer in Japanese, the same as in Caucasians. In this study, 247 type 1 diabetic patients were tested in order to clarify how the type of onset, age of onset, and duration of diabetes affect the frequency and evanescence of IA-2A. Among the young onset patients, the frequency of IA-2A was higher (52.2%), but evanescent (54.5, 66.7 and 36.7% in the insulin therapy duration ≦1, 2–5 years, and ≧6 years groups, respectively), whereas among adult onset patients, the frequency was lower (19.3%) but persistent (19.6, 13.3 and 23.5%, respectively). In addition, in the follow-up study, two of three IA-2A-positive young onset patients converted to negative in only three years, while all five adult onset patients remained positive for over 5 years. Among the adult onset patients, IA-2A frequency was similar in the slowly progressive type and the abrupt onset type. In view of the above findings, IA-2A positivity and evanescence in type 1 diabetic patients appear to be affected by age of onset, not type of onset.

Keywords:  IA-2A, GADA, Type 1 diabetes

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PII: S0168-8227(00)00168-6

Diabetes Research and Clinical Practice
Volume 50, Issue 2 , Pages 147-152, 1 October 2000

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